General
Preferred name
PHENTOLAMINE
Synonyms
PHENTOLAMINE HYDROCHLORIDE ()
PHENTOLAMINE MESYLATE ()
Phentolamine methanesulfonate ()
Phentolamine mesilate ()
Phentolamine acetate ()
Phentolamine (hydrochloride) ()
Phentolamine (mesylate) ()
NSC-757431 ()
Phentolamine hcl ()
Rogitine ()
Oraverse ()
Regitine ()
Mesylate phentolamine ()
Ryzumvi ()
NV-101 ()
Phentolamin ()
Fentolamina ()
Phentolamine-d4 (hydrochloride) ()
P&D ID
PD009843
CAS
73-05-2
65-28-1
50-60-2
249607-96-3
1346599-65-2
Tags
available
drug candidate
drug
Approved by
FDA
First approval
1952
Drug indication
Dermal necrosis
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phentolamine hydrochloride is an orally active adrenergic ¦Á receptor-blocking agent[1].
PRICE 29
DESCRIPTION Phentolamine is a non-selective alpha-adrenergic receptor antagonist. (GtoPdb)
DESCRIPTION Phentolamine is a potent, selective and orally active ¦Á1 adrenergic and ¦Á2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction[1][2][3].
PRICE 42
PRICE 35
DESCRIPTION Phentolamine acetate (3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol acetic acid) is a compound that has been shown to have anti-inflammatory and anti-cancer properties in vitro. It has also been shown to inhibit the growth of certain bacteria, including Staphylococcus aureus.
DESCRIPTION Potent and selective CRF1 antagonist; anxiolytic (Tocris Bioactive Compound Library)
DESCRIPTION ATP-sensitive K+ channel blocker; alpha adrenoceptor antagonist (LOPAC library)
DESCRIPTION Phentolamine produces its therapeutic actions by competitively blocking alpha-adrenergic receptors, leading to a muscle relaxation and a widening of the blood vessels. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. (Enamine Bioactive Compounds)
DESCRIPTION Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist used to treat hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of [RAYNAUD DISEASE] and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. (TargetMol Bioactive Compound Library)
DESCRIPTION Phentolamine mesylate is an alpha-1 and alpha-2 selective adrenergic receptor antagonist (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
37
AdooQ Bioactive Compound Library
A11734
Axon Medchem Screening Library
3510
Cayman Chemical Bioactives
16135
29417
ChEMBL Approved Drugs
CHEMBL1200873
CHEMBL597
ChEMBL Drugs
CHEMBL1204146
CHEMBL1200873
CHEMBL597
Concise Guide to Pharmacology 2017/18
502
Concise Guide to Pharmacology 2019/20
502
Concise Guide to Pharmacology 2021/22
502
Concise Guide to Pharmacology 2023/24
502
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00692
DrugBank Approved Drugs
DB00692
DrugCentral
2142
DrugCentral Approved Drugs
2142
DrugMAP
DMXYJOB
DrugMAP Approved Drugs
DMXYJOB
DrugMatrix
Enamine Bioactive Compounds
EBC-153121
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100368
Guide to Pharmacology
502
Ki Database
PHENTOLAMINE
phentolamine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL597
Mcule NIBR MoA Box Subset
MCULE-3004652227
MedChem Express Bioactive Compound Library
HY-12717A
HY-B0362A
HY-12717
NCATS Inxight Approved Drugs
Z468598HBV
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
phentolamine-mesilate
TargetMol Bioactive Compound Library
T1275
T8348
The Spectrum Collection
Tocris Bioactive Compound Library
6431
ZINC Tool Compounds
ZINC000000020251
External IDs
93
Properties
(calculated by RDKit )
Molecular Weight
281.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
2.84
TPSA
47.86
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha
Target
Adrenergic Receptor
α-adrenergic receptor
α1-adrenergic receptor
α2-adrenergic receptor
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C
a1/a2 antagonist
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Antagonist
alpha-Adrenoceptor Antagonists
Adrenergic Receptor antagonist
Member status
member
Disease Area
endocrinology, cardiology
Indication
pheochromocytoma, hypertension
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antihypertensive Agents
Source data