General
Preferred name
EPLERENONE
Synonyms
Epoxymexrenone ()
CGP 30083 ()
SC-66110 ()
Inspra ()
Eplerenone (CGP 30083) ()
CGP 30083, SC-66110 ()
SC-6611O ()
Eplerenone-d3 ()
P&D ID
PD009838
CAS
107724-20-9
Tags
natural product
drug
available
Approved by
FDA
First approval
2002
Drug Status
approved
Drug indication
Aldosterone Antagonist
Heart failure
Coronavirus Disease 2019 (COVID-19)
Antihypertensive
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Eplerenone is a potassium-sparing diuretic, which works by antagonising the effects of aldosterone.
(GtoPdb)
DESCRIPTION
Selective RARbeta2 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective mineralocorticoid receptor antagonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
24
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
414.2
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
0
cLogP
3.12
TPSA
82.2
Fraction CSP3
0.79
Chiral centers
8.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Mineralocorticoid Receptor
NR3C2
Endogenous Metabolite
Primary Target
Mineralocorticoid Receptors
MOA
Antagonist
Cytochrome P450 inhibitor
Indication
congestive heart failure, hypertension
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Antihypertensive
Therapeutic Class
Cardiovascular
Antihypertensive Agents
Antiviral Agents
Source data
