General
Preferred name
MANNITOL
Synonyms
D-Mannitol ()
DL-Mannitol ()
Mannite ()
Osmitrol ()
Aridol Kit ()
Mannitol 25 ()
Pearlitol 300 dc ()
Pearlitol 25 c ()
Crystalline mannitol fine ()
NSC-407017 ()
Bronchitol ()
E421 ()
Mannitolum ()
Mannitol 200 ()
Crystalline mannitol extra-fine ()
Pearlitol 50 c ()
INS-421 ()
Mannitol 2080 ()
Mannitol component of sorbitol- ()
Mannitol, d- ()
Pearlitol 200 sd ()
Mannitol 35 ()
Diosmol ()
E-421 ()
Mannitol 60 ()
Mannogem 2080 ()
Mannitol m300 ()
INS NO.421 ()
Manna Sugar ()
Pearlitol 160 c ()
D-(-)-mannitol ()
Mannitol 300 ()
Isomalt impurity, mannitol- ()
Resectisol ()
Cordycepic acid ()
Crystalline mannitol standard ()
P&D ID
PD009837
CAS
123897-58-5
133-43-7
69-65-8
87-78-5
Tags
available
drug
Approved by
FDA
First approval
1982
1964
Drug indication
injury
Bronchiectasis
Renal failure
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. D-Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
DESCRIPTION
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. It is a sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.
(Enamine Bioactive Compounds)
DESCRIPTION
DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
56
Molecular Weight
182.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
6
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-3.59
TPSA
121.38
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
0.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease Area
neurology/psychiatry, ophthalmology, gastroenterology
Indication
intracranial pressure, intraocular pressure, constipation
MOA
diuretic
Target
Adrenergic Receptor
Apoptosis
Endogenous Metabolite
PGC-1α
PKA
Therapeutic Class
Sweetening Agents
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
Stem Cell/Wnt
TGF-beta/Smad
Source data
