General
Preferred name
DEFEROXAMINE
Synonyms
DEFEROXAMINE MESYLATE ()
DFOM ()
Desferrioxamine B mesylate ()
desferrioxamine B ()
Deferoxamine (mesylate) ()
DEFEROXAMINE HYDROCHLORIDE ()
Deferoxamine B ()
Deferriferrioxamine B ()
Deferrioxamine ()
Deferoxamine mesylate (Ba 33112) ()
Desferrioxamine B, DFOM, NSC 644468 ()
Desferioxamine mesylate ()
Desferrioxamine Mesilate ()
Desferrioxamine Mesylate ()
Desferal ()
Deferoxamine Mesilate ()
Deferoxamini mesilas ()
BA-33112 ()
NSC-756718 ()
Desferal Mesylate ()
Deferoxamine methanesulfonate ()
Desferoxamine b ()
NSC-527604 ()
Desferrioxamine ()
Dfo-b ()
Deferoxamine hcl ()
Desferrioxamine hydrochloride ()
NSC-268993 ()
BA-29837 ()
P&D ID
PD009835
CAS
138-14-7
70-51-9
1950-39-6
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
1968
Drug Status
investigational
approved
Drug indication
Antidote (to iron poisoning)
Acute iron or aluminum toxicity
Chelating Agent,Chelating Agent (iron)
Chelating Agent
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Deferoxamine mesylate, an iron chelator, could be used in the treatment of acute iron poisoning, sickle cell diseases and it is also found to have some extent of antioxidant effects. (BOC Sciences Bioactive Compounds)
Cell lines
11
Organisms
3
Compound Sets
21
BOC Sciences Bioactive Compounds
desferioxamine-mesylate-cas-138-14-7-item-51533
Cayman Chemical Bioactives
14595
ChEMBL Approved Drugs
CHEMBL1234
CHEMBL556
ChEMBL Drugs
CHEMBL1234
CHEMBL556
CHEMBL2002581
Drug Repurposing Hub
DrugBank
DB00746
DrugBank Approved Drugs
DB00746
DrugCentral
792
DrugCentral Approved Drugs
792
DrugMAP
DMTUKZH
DrugMAP Approved Drugs
DMTUKZH
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100571
MedChem Express Bioactive Compound Library
HY-B0988
HY-B1625
NCATS Inxight Approved Drugs
J06Y7MXW4D
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
deferoxamine-mesylate
TargetMol Bioactive Compound Library
T1637
The Spectrum Collection
External IDs
79
Properties
(calculated by RDKit )
Molecular Weight
560.35
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
6
Rotatable Bonds
23
Ring Count
0
Aromatic Ring Count
0
cLogP
0.92
TPSA
205.84
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.06
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amyloid-¦Â
Iron
Ferroptosis
Amyloid-??Autophagy
Akt
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Autophagy,Beta Amyloid,Ferroptosis,HIF
Pathway
Cell Cycle/Checkpoint
Apoptosis
Autophagy
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
PI3K/Akt/mTOR
Indication
acute iron intoxication, iron overload
MOA
chelating agent
Solubility
H2O: ≥ 33 mg/mL
Source data