General
Preferred name
EPINASTINE
Synonyms
EPINASTINE HYDROCHLORIDE ()
WAL-801CL HCl ()
Alesion ()
Elestat ()
Epinastine HCl ()
Epinastine (hydrochloride) ()
epinastine, BI, nasal ()
WAL801 ()
WAL801 (hydrochloride) ()
WAL-801 ()
Purivist ()
WAL-802-CL ()
WAL-801CL ()
WAL 801 CL ()
DE-114 ()
Relestat ()
Epinastine-13C-d3 (hydrobromide) ()
P&D ID
PD009831
CAS
108929-04-0
80012-43-7
134507-59-8
80012-44-8
Tags
available
drug
Approved by
PMDA
FDA
First approval
2003
Drug Status
investigational
approved
Drug indication
Allergic conjunctivitis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Epinastine is an antihistamine. (GtoPdb)
DESCRIPTION Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for the H1 receptor and does not cross the blood-brain-barrier. It shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. It inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. It is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. It antagonises octopamine-induced cAMP formation in the insect brain. It is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance. It is produced by Allergan and marketed by Inspire in the United States. (BOC Sciences Bioactive Compounds)
DESCRIPTION Non-sedating H1 histamine receptor antagonist. (LOPAC library)
Compound Sets
21
BOC Sciences Bioactive Compounds
epinastine-cas-80012-43-7-item-401116
Cayman Chemical Bioactives
18136
30089
ChEMBL Approved Drugs
CHEMBL1106
CHEMBL1200491
ChEMBL Drugs
CHEMBL1106
CHEMBL1200491
DrugBank
DB00751
DrugBank Approved Drugs
DB00751
DrugCentral
1027
DrugCentral Approved Drugs
1027
DrugMAP
DMX0K3Q
DrugMAP Approved Drugs
DMX0K3Q
DrugMatrix
Guide to Pharmacology
7176
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1106
MedChem Express Bioactive Compound Library
HY-B0640
HY-B0640A
NCATS Inxight Approved Drugs
Q13WX941EF
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
epinastine-hcl
TargetMol Bioactive Compound Library
T6488
The Spectrum Collection
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
249.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
2.47
TPSA
41.62
Fraction CSP3
0.19
Chiral centers
1.0
Largest ring
7.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Neuronal Signaling
Target
HT
Histamine Receptor
Therapeutic Class
Antihistamines
Solubility
DMSO 57 mg/mL
Water 57 mg/mL
Source data