General
Preferred name
PROMETHAZINE
Synonyms
PROMETHAZINE HYDROCHLORIDE ()
Proazamine ()
Diphergan ()
Promethazine (HCl) ()
Phenergan58-33-3 ()
Promethazine (hydrochloride) ()
(±)-Promethazine ()
Promethazine HCl ()
Promethazine (hydrochloride) (CRM) ()
Promethazine Hydrochloride Plain ()
Promethacon ()
Zipan-50 ()
Prometh Plain ()
Anergan 25 ()
Promethazine hydrochloride component of mepergan ()
Promethazine hydrochloride component of pherazine vc ()
Phensedyl ()
Sominex ()
Zipan-25 ()
Mepergan ()
Prorex ()
Prometh Fortis ()
Promethazine Plain ()
Promethazine hydrochloride component of phenergan vc ()
Promethegan ()
Mymethazine Fortis ()
Q-Mazine ()
Genphen ()
Promethazine hydrochloride component of pherazine dm ()
Promethazine hydrochloride component of promethazine vc ()
Sarantihist ()
Phenergan ()
Promethazine hydrochloride component of promethazine dm ()
Phenhalal ()
Phenergan Nightime ()
Remsed ()
Prothazin ()
Prometazin ()
Vallergine ()
NSC-30321 ()
Protazine ()
Prometazina ()
RP-3277 ()
Dimapp ()
Fargan ()
Procit ()
Promethazine ()
(¡À)-Promethazine ()
Promethazine-d4 (hydrochloride) ()
Promethazine-d3 (hydrochloride) ()
Promethazine-d3 (hydrochloride) (CRM) ()
P&D ID
PD009828
CAS
58-33-3
16639-38-6
38878-40-9
60-87-7
1173018-74-0
1435933-86-0
Tags
available
drug
nuisance
Approved by
FDA
First approval
1951
Drug indication
Insomnia
Nausea
Middle East Respiratory Syndrome (MERS)
Severe acute respiratory syndrome (SARS)
Crohn's disease
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Promethazine hydrochloride (Promethazine HCl) , the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, moderate affinity for 5-HT2A, 5-HT2C, D2 and ??1-adrenergic receptors.
DESCRIPTION
This drug is a first-generation antihistamine with strong sedative and weak antipsychotic effects. Additional properties include antiemetic and anticholinergic actions.
(GtoPdb)
DESCRIPTION
Promethazine is an orally active histamine receptor antagonist[1]. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects[1][2][3][4].
PRICE
38
DESCRIPTION
H1 Histamine receptor antagonist; anticholinergic
(LOPAC library)
DESCRIPTION
Promethazine hydrochloride is first-generation antihistamine of the phenothiazine family used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. It shows an effect against allergy via inhibiting histamine H1.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Promethazine is a first generation histamine H1 receptor antagonist. It is also a moderate mACh receptor antagonist, has affinity to 5-HT2A, 5-HT2C, D2 and alpha-1-adrenergic receptors. Promethazine is used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
(Enamine Bioactive Compounds)
DESCRIPTION
Promethazine (Proazamine) is an analogue of anti-glaucoma prostaglandin (PG) .
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
2
Compound Sets
33
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
80
Molecular Weight
284.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.24
TPSA
6.48
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Indication
sedative, allergic rhinitis
Disease Area
neurology/psychiatry, allergy
Target
HRH1
Histamine Receptor
Adrenergic Receptor
mAChR
5-HT
CAM
D2
H1 receptor
MOA
Histamine Receptor antagonist
Therapeutic Class
Antiallergic Agents
Antiviral Agents
Solubility
Soluble in DMSO
Source data
