General
Preferred name
PROMETHAZINE
Synonyms
PROMETHAZINE HYDROCHLORIDE ()
Proazamine ()
Diphergan ()
Promethazine (HCl) ()
Promethazine (hydrochloride) ()
Phenergan58-33-3 ()
Promethazine HCl ()
Promethazine Plain ()
Phenergan Nightime ()
Prometh Fortis ()
Sarantihist ()
Promethazine Hydrochloride Plain ()
Promethegan ()
Remsed ()
Promethacon ()
Promethazine ()
Zipan-50 ()
Prometh Plain ()
Phenergan ()
Q-Mazine ()
Mymethazine Fortis ()
Sominex ()
Phenhalal ()
Phensedyl ()
Zipan-25 ()
Fargan ()
RP-3277 ()
Dimapp ()
Protazine ()
NSC-30321 ()
Prometazin ()
Vallergine ()
Prothazin ()
Procit ()
Promethazine (hydrochloride) (CRM) ()
P&D ID
PD009828
CAS
58-33-3
60-87-7
16639-38-6
38878-40-9
Tags
nuisance
natural product
drug
available
Approved by
FDA
First approval
1951
Drug Status
investigational
approved
Drug indication
Anti-Emetic
Antihistaminic
Severe acute respiratory syndrome (SARS)
Nausea
Middle East Respiratory Syndrome (MERS)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This drug is a first-generation antihistamine with strong sedative and weak antipsychotic effects. Additional properties include antiemetic and anticholinergic actions. (GtoPdb)
DESCRIPTION H1 Histamine receptor antagonist; anticholinergic (LOPAC library)
DESCRIPTION Promethazine hydrochloride is first-generation antihistamine of the phenothiazine family used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. It shows an effect against allergy via inhibiting histamine H1. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
32
BOC Sciences Bioactive Compounds
promethazine-hydrochloride-cas-58-33-3-303878
Cayman Chemical Bioactives
16478
21331
22450
ChEMBL Approved Drugs
CHEMBL1200750
CHEMBL643
ChEMBL Drugs
CHEMBL1200750
CHEMBL643
Concise Guide to Pharmacology 2017/18
7282
Concise Guide to Pharmacology 2019/20
7282
Concise Guide to Pharmacology 2021/22
7282
Concise Guide to Pharmacology 2023/24
7282
Drug Repurposing Hub
DrugBank
DB01069
DrugBank Approved Drugs
DB01069
DrugCentral
2286
DrugCentral Approved Drugs
2286
DrugMAP
DM6I5GR
DMY3VGC
DrugMAP Approved Drugs
DM6I5GR
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101840
Guide to Pharmacology
7282
Ki Database
PROMETHAZINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200750
CHEMBL643
MedChem Express Bioactive Compound Library
HY-B0781
NCATS Inxight Approved Drugs
FF28EJQ494
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
promethazine-hcl
promethazine
TargetMol Bioactive Compound Library
T0445
The Spectrum Collection
External IDs
73
Properties
(calculated by RDKit )
Molecular Weight
284.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.24
TPSA
6.48
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Neuronal Signaling
Target
5-HT
mAChR
Adrenergic Receptor
CAM
D2
H1 receptor
HRH1
Histamine Receptor
Indication
sedative, allergic rhinitis
Disease Area
neurology/psychiatry, allergy
MOA
Histamine Receptor antagonist
Therapeutic Class
Antiallergic Agents
Antiviral Agents
Solubility
Soluble in DMSO
Source data