General
Preferred name
dihydrotachysterol
Synonyms
Hytakerol ()
Tachysterol dihydro derivative ()
Dihydral ()
Dygratyl ()
Dihydrotachysterol2 ()
A.T. 10 ()
Dihydrotachysterol 2 ()
Dihidrotaquisterol ()
Tachyrol ()
P&D ID
PD009827
CAS
67-96-9
Tags
available
drug
Drug indication
Hypocalcemia
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) [1][2].
PRICE
380
DESCRIPTION
Dihydrotachysterol (HSDB 3314) is a vitamin D analog.Dihydrotachysterol has been used to study hypocalcemic hypoparathyroidism after surgical removal of the parathyroid glands and growth impairment in children with chronic renal insufficiency.
DESCRIPTION
Dihydrotachysterol is a vitamin D that can be regarded as a reduction product of vitamin D2 activated in the liver. It does not require renal hydroxylation like vitamin D2 and vitamin D3. It could stimulate intestinal calcium absorption and increases renal phosphate excretion. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NPC Screening Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
398.35
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
0
cLogP
7.72
TPSA
20.23
Fraction CSP3
0.79
Chiral centers
7.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
VD/VDR
Therapeutic Class
Antihypoparathyroid Agents
Pathway
Vitamin D Related/Nuclear Receptor
Solubility
Soluble in Chloroform (Slightly), Methanol (Slightly)
Source data
