General
Preferred name
dihydrotachysterol
Synonyms
Vitamin D1 ()
Dihydrotachysterol2 ()
Hytakerol ()
Dichysterol ()
Dygratyl ()
A.T. 10 ()
Dihydrotachysterol 2 ()
Tachysterol dihydro derivative ()
Dihydral ()
Tachyrol ()
P&D ID
PD009827
CAS
67-96-9
Tags
natural product
drug
available
Drug Status
approved
Drug indication
Hypocalcemia
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dihydrotachysterol is a vitamin D that can be regarded as a reduction product of vitamin D2 activated in the liver. It does not require renal hydroxylation like vitamin D2 and vitamin D3. It could stimulate intestinal calcium absorption and increases renal phosphate excretion. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NPC Screening Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
398.35
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
0
cLogP
7.72
TPSA
20.23
Fraction CSP3
0.79
Chiral centers
7.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antihypoparathyroid Agents
Pathway
Vitamin D Related/Nuclear Receptor
Target
VD/VDR
Solubility
Soluble in Chloroform (Slightly), Methanol (Slightly)
Source data
