General
Preferred name
DIPHENOXYLATE
Synonyms
DIPHENOXYLATE HYDROCHLORIDE ()
Difenoxilato ()
IDS-ND-016 ()
R-1132 (ANTIPERISTALTIC) ()
Diphenoxylate hydrochloride component of lonox ()
Diphenoxylate hydrochloride component of colonaid ()
Diphenoxylate hydrochloride component of di-atro ()
Diphenoxylate hydrochloride cii ()
Diphenoxylate hydrochloride component of lo-trol ()
Diphenoxylate HCl ()
Diphenoxylate hydrochloride component of logen ()
Diphenoxylate hydrochloride component of lomanate ()
Diphenoxylate hydrochloride component of lomotil ()
Diphenoxylati hydrochloridum ()
Diphenoxylate hydrochloride component of low-quel ()
P&D ID
PD009819
CAS
915-30-0
3810-80-8
Tags
available
drug
Approved by
FDA
First approval
1960
Drug indication
Diarrhea
Drug Status
approved
illicit
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Diphenoxylate is a phenylpiperidine series, centrally-active opioid antidiarrheal drug. Diphenoxylate is metabolised in vivo to form . Both diphenoxylate and difenoxin can be prescribed in fixed-dose combination with atropine to act as an abuse deterrent. Atropine causes severe weakness and nausea if standard doses are exceeded.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
452.25
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
5.48
TPSA
53.33
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Analgesics
Source data
