General
Preferred name
pilocarpine
Synonyms
PILOCARPINE NITRATE ()
PILOCARPINE HYDROCHLORIDE ()
(+)-Pilocarpine hydrochloride ()
Pilofrin ()
Pilocarpine (Hydrochloride) ()
Pilocarpine (nitrate) ()
NSC 5746 HCl ()
Pilocarpine HCl ()
(+)-Pilocarpine (hydrochloride) ()
Piloc Nit ()
NSC-757282 ()
Pilocarpine mononitrate ()
Pilocarpinum nitricum ()
Pilocarpine subnitrate ()
Pilagan ()
Pilocarpini nitras ()
Pilocarpine hydrochloride component of betoptic pilo ()
Qlosi ()
Salagen ()
Vistacarpin n ()
Pilocarpine monohydrochloride ()
Pilocarpinum muriaticum ()
Vuity ()
Sno Pilo ()
Isopto Carpine ()
Pilopine Hs ()
Pilogel ()
Pilopine ()
Pilocarpini hydrochloridum ()
Piloc HCl ()
Ocusert ()
Pilocarpol ()
Ocucarpine ()
Ocusert pilo-20 ()
Spersacarpine ()
Pilocarpinum ()
Ocusert pilo ()
Pilokarpin ()
Ocusert pilo-40 ()
Syncarpine ()
(+)-Pilocarpine-d3 (hydrochloride) ()
P&D ID
PD009816
CAS
148-72-1
54-71-7
91484-73-0
102282-25-7
92-13-7
Tags
available
drug candidate
drug
biased GPCR ligand
Approved by
FDA
First approval
1974
1984
Drug indication
Urinary incontinence
head and neck malignant neoplasia
Glaucoma/ocular hypertension
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
DESCRIPTION Pilocarpine is a parasympathomimetic alkaloid type cholinergic drug, exerting its clinical effects via activation of muscarinic acetylcholine M3 receptors. (GtoPdb)
DESCRIPTION Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
DESCRIPTION Nonselective muscarinic acetylcholine receptor agonist (LOPAC library)
DESCRIPTION Potent and selective kappa agonist (Tocris Bioactive Compound Library)
DESCRIPTION Muscarinic agonist (Tocriscreen Plus)
DESCRIPTION Cholinergic receptor agonist (LOPAC library)
DESCRIPTION Muscarinic agonist (Tocriscreen Total)
Compound Sets
33
BiasDB
Pilocarpine
Cayman Chemical Bioactives
14487
29078
ChEMBL Approved Drugs
CHEMBL1200330
CHEMBL550
ChEMBL Drugs
CHEMBL1213136
CHEMBL1200330
CHEMBL550
Concise Guide to Pharmacology 2017/18
305
Concise Guide to Pharmacology 2019/20
305
Concise Guide to Pharmacology 2021/22
305
Concise Guide to Pharmacology 2023/24
305
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01085
DrugBank Approved Drugs
DB01085
DrugCentral
2166
DrugCentral Approved Drugs
2166
DrugMAP
DMV9ADG
DrugMAP Approved Drugs
DMV9ADG
Guide to Pharmacology
305
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL550
Mcule NIBR MoA Box Subset
MCULE-8737728813
MedChem Express Bioactive Compound Library
HY-B1006
HY-B0726
HY-B0726A
NCATS Inxight Approved Drugs
01MI4Q9DI3
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
pilocarpine-hcl
The Spectrum Collection
Tocris Bioactive Compound Library
0694
Tocriscreen Plus
0694
Tocriscreen Total
External IDs
87
Properties
(calculated by RDKit )
Molecular Weight
208.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.16
TPSA
44.12
Fraction CSP3
0.64
Chiral centers
2.0
Largest ring
5.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
Muscarinic
Primary Target
Non-selective Muscarinics
MOA
Agonist
Muscarinic Agonists
acetylcholine receptor agonist
Member status
virtual
Indication
glaucoma, hypertension
Disease Area
ophthalmology, cardiology
Target
CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
mAChR
AChR
Therapeutic Class
Cholinergic Agents
Pathway
GPCR/G protein
Neuronal Signaling
Source data