General
Preferred name
pilocarpine
Synonyms
PILOCARPINE NITRATE ()
PILOCARPINE HYDROCHLORIDE ()
(+)-Pilocarpine hydrochloride ()
Pilocarpine HCl ()
NSC 5746 HCl ()
Pilofrin ()
Pilocarpine (Hydrochloride) ()
Pilocarpine (nitrate) ()
Pilagan ()
NSC-757282 ()
Piloc Nit ()
Pilocarpinum nitricum ()
Pilocarpine mononitrate ()
Pilocarpini nitras ()
Pilocarpine subnitrate ()
Piloc HCl ()
Isopto Carpine ()
Pilocarpinum muriaticum ()
Pilopine ()
Pilocarpine monohydrochloride ()
Vistacarpin n ()
Sno Pilo ()
Vuity ()
Pilocarpini hydrochloridum ()
Pilopine Hs ()
Pilogel ()
Ocusert ()
Salagen ()
Pilocarpinum ()
Ocucarpine ()
Pilocarpol ()
Syncarpine ()
Ocusert pilo-20 ()
Ocusert pilo-40 ()
Ocusert Pilo ()
Spersacarpine ()
Pilokarpin ()
(+)-Pilocarpine (hydrochloride) ()
(+)-Pilocarpine-d3 (hydrochloride) ()
P&D ID
PD009816
CAS
148-72-1
54-71-7
91484-73-0
102282-25-7
92-13-7
Tags
drug
natural product
biased GPCR ligand
available
Approved by
FDA
First approval
1984
1974
Drug Status
investigational
approved
Drug indication
Cholinergic (ophthalmic),Cholinergic (ophthalmic)
Antiglaucoma Agent
Glaucoma/ocular hypertension
Cholinergic (ophthalmic)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pilocarpine is a parasympathomimetic alkaloid type cholinergic drug, exerting its clinical effects via activation of muscarinic acetylcholine M3 receptors. (GtoPdb)
DESCRIPTION Potent and selective kappa agonist (Tocris Bioactive Compound Library)
DESCRIPTION Muscarinic agonist (Tocriscreen Plus)
DESCRIPTION Nonselective muscarinic acetylcholine receptor agonist (LOPAC library)
DESCRIPTION Cholinergic receptor agonist (LOPAC library)
DESCRIPTION Muscarinic agonist (Tocriscreen Total)
Compound Sets
33
BiasDB
Pilocarpine
Cayman Chemical Bioactives
14487
29078
ChEMBL Approved Drugs
CHEMBL1213136
CHEMBL1200330
CHEMBL550
ChEMBL Drugs
CHEMBL1213136
CHEMBL1200330
CHEMBL550
Concise Guide to Pharmacology 2017/18
305
Concise Guide to Pharmacology 2019/20
305
Concise Guide to Pharmacology 2021/22
305
Concise Guide to Pharmacology 2023/24
305
Drug Repurposing Hub
DrugBank
DB01085
DrugBank Approved Drugs
DB01085
DrugCentral
2166
DrugCentral Approved Drugs
2166
DrugMAP
DMV9ADG
DrugMAP Approved Drugs
DMV9ADG
Guide to Pharmacology
305
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL550
Mcule NIBR MoA Box Subset
MCULE-8737728813
MedChem Express Bioactive Compound Library
HY-B1006
HY-B0726
HY-B0726A
NCATS Inxight Approved Drugs
01MI4Q9DI3
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
pilocarpine-hcl
TargetMol Bioactive Compound Library
T0804
The Spectrum Collection
Tocris Bioactive Compound Library
0694
Tocriscreen Plus
0694
Tocriscreen Total
External IDs
80
Properties
(calculated by RDKit )
Molecular Weight
208.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.16
TPSA
44.12
Fraction CSP3
0.64
Chiral centers
2.0
Largest ring
5.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
Muscarinic
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Target
mAChR
CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
AChR
Primary Target
Non-selective Muscarinics
MOA
Agonist
Muscarinic Agonists
acetylcholine receptor agonist
Member status
virtual
Indication
glaucoma, hypertension
Disease Area
ophthalmology, cardiology
Therapeutic Class
Cholinergic Agents
Source data