General
Preferred name
ILOPROST
Synonyms
Ciloprost ()
ZK 36374 ()
Endoprost ()
ZK-36374 ()
ZK-00036374 ()
ZK 00036374 ()
Ventavis ()
Ilomedin ()
[3H]iloprost ()
P&D ID
PD009814
CAS
78919-13-8
Tags
available
probe
natural product
drug
Approved by
FDA
First approval
2004
Drug Status
investigational
approved
Drug indication
Pulmonary arterial hypertension
Max Phase
Phase 4
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
21
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Probe Miner (suitable probes)
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
360.23
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
0
cLogP
3.54
TPSA
77.76
Fraction CSP3
0.68
Chiral centers
6.0
Largest ring
5.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Prostanoid IP receptor
Endogenous Metabolite
Prostaglandin Receptor
MOA
prostaglandin receptor agonist
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Source data
