General
Preferred name
ILOPROST
Synonyms
Ciloprost ()
ZK 36374 ()
ILOPROST TROMETHAMINE ()
ENDOPROST ()
ZK 00036374 ()
Aurlumyn ()
ZK-36374 ()
Ilomedin ()
VENTAVIS ()
ZK-00036374 ()
[3H]iloprost ()
Ciloprost trometamol ()
Iloprost trometamol ()
Trometamol iloprost ()
AURLUMYN ()
Iloprost-d4 ()
P&D ID
PD009814
CAS
78919-13-8
Tags
probe
drug
available
Approved by
FDA
First approval
2004
2003
Drug indication
Pulmonary arterial hypertension
Drug Status
approved
investigational
Max Phase
4.0
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
family-selective
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.
DESCRIPTION Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research[1][2][3][4].
Cell lines
1
Organisms
2
Compound Sets
24
Cayman Chemical Bioactives
18215
9000366
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL494
CHEMBL5315118
ChEMBL Drugs
CHEMBL494
CHEMBL5315118
Concise Guide to Pharmacology 2017/18
1966
Concise Guide to Pharmacology 2019/20
1966
Concise Guide to Pharmacology 2021/22
1966
Concise Guide to Pharmacology 2023/24
1966
CZ-OPENSCREEN Bioactive Library
DrugBank
DB01088
DrugBank Approved Drugs
DB01088
DrugCentral
1422
DrugCentral Approved Drugs
1422
DrugMAP
DMVPZBE
DrugMAP Approved Drugs
DMVPZBE
EUbOPEN Chemogenomics Library
EUB0001871
Guide to Pharmacology
1966
High-quality chemical probes
PD009814
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL494
MedChem Express Bioactive Compound Library
HY-A0096
NCATS Inxight Approved Drugs
JED5K35YGL
NPC Screening Collection
Probe Miner (suitable probes)
P43119/1687997
ReFrame library
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
360.23
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
0
cLogP
3.54
TPSA
77.76
Fraction CSP3
0.68
Chiral centers
6.0
Largest ring
5.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Prostanoid IP receptor
Endogenous Metabolite
Prostaglandin Receptor
MOA
prostaglandin receptor agonist
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Recommended Cell Concentration
None
Source data