General
Preferred name
DESERPIDINE
Synonyms
Harmonyl ()
NSC-72138 ()
Recanescin ()
Halmonyl ()
Deserpidine, (-)- ()
P&D ID
PD009813
CAS
131-01-1
959244-16-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1957
Drug Status
approved
withdrawn
Drug indication
Hypertension
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Deserpidine is chemically related to .
(GtoPdb)
DESCRIPTION
Deserpidine is an antihypertensive drug related to Reserpine. It is naturally found in Rauvolfia spp. Deserpidine is a competitive ACE (angiotensin converting enzyme) inhibitor. Deserpidine can block the conversion of angiotensin I to angiotensin II as a potent vasoconstrictor through competing with angiotensin I for ACE. Reduced level of serum angiotensin II leads to a decrease in blood pressure. Deserpidine can also decrease angiotensin II-induced aldosterone secretion by the adrenal cortex.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
578.26
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
6
Aromatic Ring Count
3
cLogP
4.16
TPSA
108.55
Fraction CSP3
0.5
Chiral centers
6.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Metabolic Enzyme/Protease
Target
ACE
ACE, SLC18A2
Angiotensin-converting Enzyme (ACE)
Indication
hypertension
MOA
angiotensin converting enzyme inhibitor
ATC
C02AA05
Therapeutic Class
Antihypertensive Agents
Solubility
Chloroform (Slightly), Methanol (Slightly)
Source data
