General
Preferred name
TRILOSTANE
Synonyms
Win 24540 ()
Desopan ()
NSC-758904 ()
Modrenal ()
WIN 24,540 ()
WIN-24540 ()
Modrastane ()
P&D ID
PD009803
CAS
13647-35-3
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
withdrawn
approved
vet_approved
Drug indication
Cushing disease
Adrenocortical Suppressant
Max Phase
Phase 4
First approval
1984
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Trilostane is a 3 β-hydroxysteroid dehydrogenase (gene symbol HSD3B1) inhibitor. It is now used mainly in veterinary practice.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
329.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
0
cLogP
3.47
TPSA
76.78
Fraction CSP3
0.85
Chiral centers
8.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
3-beta-hydroxysteroid dehydrogenase inhibitor
Target
3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II
3 ??-hydroxysteroid dehydrogenase
3ß-HSD inhibitor
Dehydrogenase
Pathway
Metabolism
ATC
H02CA01
Source data
