General
Preferred name
CEFUROXIME
Synonyms
Cefuroxime sodium salt ()
Anaptivan ()
Biociclin ()
CEFUROXIME SODIUM ()
Cefuroxime (sodium) ()
Cefuroxime ()
Britacef ()
Kefurox ()
Zinacef ()
Sodium cefuroxime ()
Cefuroximine ()
640/359 ()
Cefuroxime acid ()
Cefuroxime (sodium salt) ()
Cefuroxime-d3 ()
P&D ID
PD009800
CAS
55268-75-2
56238-63-2
153012-39-6
1803240-98-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1983
Drug Status
approved
Drug indication
Antibacterial
Acute bronchitis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cefuroxime is a semisynthetic, second-generation cephalosporin antibacterial. It has broad-spectrum activity and is β-lactamase-resistant. Oral formulations contain the prodrug cefuroxime axetil. (GtoPdb)
Compound Sets
20
Cayman Chemical Bioactives
23627
31163
ChEMBL Approved Drugs
CHEMBL2146124
CHEMBL1436
ChEMBL Drugs
CHEMBL2146124
CHEMBL1436
Drug Repurposing Hub
DrugBank
DB01112
DrugBank Approved Drugs
DB01112
DrugCentral
565
DrugCentral Approved Drugs
565
DrugMAP
DMSIMD8
DrugMAP Approved Drugs
DMSIMD8
Guide to Pharmacology
10900
MedChem Express Bioactive Compound Library
HY-B1256
NCATS Inxight Approved Drugs
O1R9FJ93ED
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F78DA2792E0
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
cefuroxime-sodium
TargetMol Bioactive Compound Library
T1224
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
424.07
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
1
cLogP
-0.54
TPSA
173.76
Fraction CSP3
0.31
Chiral centers
2.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
antibiotic
Bacterial
Beta-lactamase
¦Â-Lactamase
MOA
Antibiotic
bacterial cell wall synthesis inhibitor
Indication
gram-negative bacterial infections
Therapeutic Class
Antibiotics
Source data