General
Preferred name
CEFUROXIME
Synonyms
Biociclin ()
Cefuroxime sodium salt ()
Anaptivan ()
Ketocef ()
Cephuroxime ()
Cefuroxime (sodium) ()
Kefurox ()
CEFUROXIME SODIUM ()
Cefuroxime (sodium salt) ()
Cefuroxime ()
Britacef ()
Zinacef ()
Sodium cefuroxime ()
Cefuroxima ()
Cefuroximine ()
Cefuroxime acid ()
640/359 ()
Cefuroxime-d3 ()
P&D ID
PD009800
CAS
55268-75-2
153012-39-6
56238-63-2
1803240-98-3
Tags
available
drug
Approved by
FDA
First approval
1983
Drug indication
Acute bronchitis
infection
Pneumonia
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to ¦Â-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1].
DESCRIPTION
Cefuroxime is a semisynthetic, second-generation cephalosporin antibacterial. It has broad-spectrum activity and is β-lactamase-resistant. Oral formulations contain the prodrug cefuroxime axetil.
(GtoPdb)
PRICE
29
DESCRIPTION
Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to ¦Â-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1].
DESCRIPTION
Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic with bactericidal activity. Cefuroxime sodium (Cefuroxime sodium salt) inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Cefuroxime is a cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo.
(Enamine Bioactive Compounds)
DESCRIPTION
Cefuroxime (Cephuroxime) is an orally active second-generation cephalosporin antibiotic with antimicrobial activity that inhibits both Gram-positive and Gram-negative bacteria, and is used in the study of soft tissue infections.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Guide to Pharmacology
NCATS Inxight Approved Drugs
NPC Screening Collection
NURSA ligand set
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
66
Molecular Weight
424.07
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
1
cLogP
-0.54
TPSA
173.76
Fraction CSP3
0.31
Chiral centers
2.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
β-Lactamase
Beta-lactamase
¦Â-Lactamase
MOA
Antibiotic
bacterial cell wall synthesis inhibitor
Indication
gram-negative bacterial infections
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data
