General
Preferred name
PAPAVERINE
Synonyms
PAPAVERINE HYDROCHLORIDE ()
papaverine, S-P ()
Papaverini hydrochloridum ()
Papaverine hcl ()
Artegodan ()
NSC-35443 ()
Pavabid ()
Cardoverina ()
Papaver HCl ()
Vasorin ()
Papaverinum ()
NSC-136630 ()
Papaverine ()
Papaverine (hydrochloride) ()
P&D ID
PD009799
CAS
61-25-6
58-74-2
132-40-1
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
Drug indication
Spasm
Relaxant (smooth muscle)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Phosphodiesterase inhibitor
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
7
Compound Sets
21
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LOPAC library
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
56
Molecular Weight
339.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.86
TPSA
49.81
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PDE
Member status
virtual
MOA
Phosphodiesterase PDE10A Inhibitors
phosphodiesterase inhibitor
Disease Area
cardiology, hematology, gastroenterology
Indication
myocardial infarction, angina pectoris, pulmonary embolism (PE), colitis, vascular spasm
Target
PDE10A, PDE4B, PDE5A
Therapeutic Class
Vasodilator Agents
Source data
