General
Preferred name
CHLORPHENIRAMINE
Synonyms
CHLORPHENIRAMINE MALEATE ()
Chlor-trimeton ()
(±)-Chlorpheniramine maleate ()
CHEMBL505 ()
DEXCHLORPHENIRAMINE ()
NCI-C55265 ()
Chlorphenamine maleate ()
d-Chlorpheniramine ()
5-HT,N-ACETYL ()
chlorphenamine ()
Chlorpheniramine113-92-8 ()
Chlorpheniramine (maleate) ()
Chlorpheniramine maleate ()
Piriton Allergy ()
Rhino-Syrup Allergy ()
Neorestamin ()
Piriject ()
Chlorpheniramine maleate component of drize ()
Teldrin ()
Alunex ()
Allerief ()
Piriton ()
Chlorpheniramine maleate component of triaminic ()
Chlorphenamine hydrogen maleate ()
NSC-756684 ()
Pyridamal 100 ()
Rimarin ()
Chlorpheniramine maleate component of contac ()
Phenetron ()
Efidac 24 Chlorpheniramine Maleate ()
Chlorpheniramine maleate component of vituz ()
Pyridamal ()
Chlorphenamini hydrogenomaleas ()
Efidac ()
Chlorpheniramine maleate component of ornade ()
Hayleve ()
Chlorpheniramine maleate component of zutripro ()
Histaspan ()
Synistamin ()
Kloromin ()
(+)-Chlorpheniramine Maleate ()
Chlorpheniramine maleate component of demazin ()
Calimal ()
ALLERcalm Allergy Relief ()
Chlorpheniramine maleate component of codimal-l.a. 12 ()
Chlorpheniramine maleate component of isoclor ()
Antagonate ()
Chlorpheniramine maleate component of advil allergy sinus ()
Clorfenamina ()
Isoclor ()
Chlorpheniramine ()
Сhlorphenamine maleate ()
Chlorpheniramine-d6 (maleate) ()
P&D ID
PD009798
CAS
132-22-9
7054-11-7
113-92-8
1219806-45-7
Tags
available
probe
drug
Approved by
FDA
First approval
1950
Drug indication
Seasonal allergic rhinitis
Allergic rhinitis
Drug Status
approved
Max Phase
4.0
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].
PRICE 260
TOXICITY Oral LD50 (rat): 306 mg/kg; Oral LD50 (mice): 130 mg/kg; Oral LD50 (guinea pig): 198 mg/kg [Registry of Toxic Effects of Chemical Substances. Ed. D. Sweet, US Dept. of Health & Human Services: Cincinatti, 2010.] ; Also a mild reproductive toxin to women of childbearing age.
DESCRIPTION The approved drug is a racemic mixture of stereoisomers; (R-isomer) and (S-isomer). We show the non-isomeric molecule to represent the mixture. (GtoPdb)
DESCRIPTION Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research[1][2].
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
DESCRIPTION Chlorpheniramine is a histamine-H1 receptor antagonist. (Enamine Bioactive Compounds)
DESCRIPTION Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
1
Compound Sets
31
AdooQ Bioactive Compound Library
A10205
Cayman Chemical Bioactives
21253
35767
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1659
CHEMBL505
ChEMBL Drugs
CHEMBL1659
CHEMBL505
CZ-OPENSCREEN Bioactive Library
DrugBank
DB01114
DrugBank Approved Drugs
DB01114
DrugCentral
616
DrugCentral Approved Drugs
616
DrugMAP
DM5URA2
DrugMAP Approved Drugs
DM5URA2
DrugMatrix
Enamine Bioactive Compounds
EBC-13382
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101431
Guide to Pharmacology
6976
Ki Database
5-HT,N-ACETYL
CHLORPHENIRAMINE
d-Chlorpheniramine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL505
MedChem Express Bioactive Compound Library
HY-B0286A
HY-B0286
NCATS Inxight Approved Drugs
3U6IO1965U
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Chlorpheniramine-maleate
TargetMol Bioactive Compound Library
T1553
The Spectrum Collection
Tool Compound Set
External IDs
75
Properties
(calculated by RDKit )
Molecular Weight
274.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.82
TPSA
16.13
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Target
Histamine H1 receptor
Histamine Receptor
H1 receptor
MOA
Histamine Receptor antagonist
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Therapeutic Class
Antiallergic Agents
Source data