General
Preferred name
AMIODARONE
Synonyms
AMIODARONE HYDROCHLORIDE ()
Nexterone ()
Amiodarone HCl ()
Amiodar HCl ()
Aratac ()
Amiodarona ()
PM-101 ()
Amiodaronum ()
Cordarone ()
Amiodarone (HCl) ()
Amiodarone (hydrochloride) ()
Amiodar,Amiodarone hydrochloride,Nexterone ()
Amiodarone (NSC 85442) HCl ()
MIODARON ()
DARMIL ()
L-3428 ()
SKF 33134-A ()
CORDARONE X ()
Pacerone ()
SKF-33134-A ()
Amiodar ()
ORTACRONE ()
Amidox ()
NSC-343341 ()
AMYBEN ()
NSC-85442 ()
SK&F-33134-A ()
TRANGOREX ()
CORDARONE X 100 ()
RITMOCARDYL ()
VF-236 ()
CORDARONE X 200 ()
Amiodarone ()
Amiodarone-d4 (hydrochloride) ()
P&D ID
PD009796
CAS
19774-82-4
1951-25-3
1216715-80-8
Tags
available
drug
nuisance
obsolete probe
Approved by
FDA
First approval
1985
Drug indication
Atrial fibrillation
Ventricular tachycardia
Coronavirus Disease 2019 (COVID-19)
Tachyarrhythmias
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ¡«45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].
PRICE
29
METABOLISM
Amiodarone is extensively metabolized in the liver via CYP2C8 (under 1% unchanged in urine), and can effect the metabolism of numerous other drugs. The major metabolite of amiodarone, desethylamiodarone (DEA), also exhibits antiarrhythmic properties.
DESCRIPTION
Amiodarone is a class III antiarrhythmic drug and acts as a positive inotropic agent. The prescription drug contains amiodarone hydrochloride (PubChem CID 441325).
(GtoPdb)
PHARMACODYNAMICS
Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It also mediates effects that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.
DESCRIPTION
Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 ¦ÌM.
PRICE
127
DESCRIPTION
alpha and beta adrenoceptor agonist; inhibits binding of 1,4-dihydropyridine to L-type Ca2+ channels; coronary vasodilator
(LOPAC library)
DESCRIPTION
Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Inhibitor of neuronal NaV channels; anticonvulsant
(Tocris Bioactive Compound Library)
DESCRIPTION
Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel.
(Enamine Bioactive Compounds)
DESCRIPTION
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Amiodarone (Cordarone) is an antiarrhythmic compound that induces pulmonary toxicity and inhibits ATP-sensitive potassium channels.Amiodarone has shown some antiviral activity in SARS-CoV-2-induced disease.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
3
Compound Sets
38
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Obsolete Compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
78
Molecular Weight
645.02
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
11
Ring Count
3
Aromatic Ring Count
3
cLogP
6.94
TPSA
42.68
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.17
Structural alerts
4
aggregator (Aggregator Advisor)
Aggregators
historic compounds (Chemical Probes.org)
Obsolete
aggregator (ZINC)
Aggregators
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha/beta
Pathway
Autophagy
GPCR/G protein
Membrane Transporter/Ion Channel
Neuroscience
Primary Target
Other Channel Modulators
Target
ADRB1, CACNA1H, CACNA2D2, KCNA7, KCNH2
Potassium Channel
Autophagy,Potassium Channel
ATP-sensitive potassium (KATP) channels
β-adrenergic receptor
Indication
ventricular arrhythmias
MOA
potassium channel blocker
Therapeutic Class
Antiarrhythmic Agents
Antiviral Agents
Nuisance MOA
CAD
Targets
Sigma opioid receptor
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
HERG
Recommended Cell Concentration
None
Source data
