General
Preferred name
ECONAZOLE
Synonyms
ECONAZOLE NITRATE ()
(¡À)-Econazol ()
(±)-Econazol ()
NSC 243115 ()
Econail ()
Econazole Nitrate24169-02-6 ()
Econazole (nitrate) ()
NSC 243115,Spectazole ()
Spectazole ()
SQ-13050 ()
Gyno-Pevaryl ()
Gyno-Pevaryl 150 ()
R 14,827 ()
SQ13050 ()
Gyno-Pevaryl Once ()
Pevaryl ()
Gyno-Pevaryl 1 Cp Pack ()
Ecostatin-1 ()
Ecoza ()
Ecostatin ()
R-14827 ()
R14827 ()
NSC-243115 ()
SQ 13050 ()
Ecostatin Twin Pack ()
Econazol ()
NSC-187789 ()
P&D ID
PD009791
CAS
68797-31-9
27220-47-9
24169-02-6
73094-40-3
73094-38-9
Tags
available
drug
Approved by
FDA
First approval
1982
Drug indication
Tinea cruris
Cutaneous candidiasis
Tinea pedis
Tinea versicolor
Fungal infection
Tinea corporis
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Econazole nitrate is an imidazole class antifungal medication[1]. Econazole nitrate also has antibacterial activity[2].
DESCRIPTION Econazole topical is an antifungal agent. The preparation of econazole specified by the INN document is a racemic mixture of an (R)- and an (S)- isomer. The structure shown here does not specify stereochemistry and represents the mixture.
Marketed formulations may contain econazole nitrate (PubChem CID 68589). (GtoPdb)
PRICE 29
DESCRIPTION Econazole ((¡À)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage[1][2][3][4][5].
DESCRIPTION Econazole ((??)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.
DESCRIPTION Econazole nitrate (NSC-243115) (Spectazole) is an imidazole class antifungal medicine. (TargetMol Bioactive Compound Library)
DESCRIPTION Econazole is a topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. (Enamine Bioactive Compounds)
DESCRIPTION Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
6
Compound Sets
29
AdooQ Bioactive Compound Library
A10342
Cayman Chemical Bioactives
20223
ChEMBL Approved Drugs
CHEMBL1201049
CHEMBL808
ChEMBL Drugs
CHEMBL1201049
CHEMBL808
Concise Guide to Pharmacology 2017/18
2446
Concise Guide to Pharmacology 2019/20
2446
Concise Guide to Pharmacology 2021/22
2446
Concise Guide to Pharmacology 2023/24
2446
CZ-OPENSCREEN Bioactive Library
DrugBank
DB01127
DrugBank Approved Drugs
DB01127
DrugCentral
983
DrugCentral Approved Drugs
983
DrugMAP
DM1LDIP
DMFSWGH
DrugMAP Approved Drugs
DMFSWGH
DrugMatrix
Enamine Bioactive Compounds
EBC-26869
EU-OPENSCREEN Bioactive Compound Library
EOS101690
Guide to Pharmacology
2446
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL808
MedChem Express Bioactive Compound Library
HY-B0453
HY-B0885
NCATS Inxight Approved Drugs
6Z1Y2V4A7M
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Econazole-nitrate-Spectazole
econazole
TargetMol Bioactive Compound Library
T0444L
T0444
The Spectrum Collection
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
380.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
5.8
TPSA
27.05
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Anti-infection
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Target
antibiotic
Bacterial
Fungal
Calcium Channel
Cytochrome P450
Calcium Channel,Fungal
14-α Demethylase
Therapeutic Class
Antifungal Agents
Source data