General
Preferred name
CLOXACILLIN
Synonyms
CLOXACILLIN SODIUM ()
Cloxacillin sodium salt ()
Cloxacillin (sodium) ()
CLOXACILLIN BENZATHINE ()
Cloxacillin (sodium salt) ()
OXACILLIN SODIUM SALT ()
Orbenin ()
Cloxacilline ()
Cloxacilina ()
Benzathine cloxacillin ()
Cloxacillin benzathine salt ()
P&D ID
PD009778
CAS
7081-44-9
642-78-4
1252-37-5
61-72-3
50763-55-8
23736-58-5
Tags
available
covalent binder
drug
drug candidate
Approved by
FDA
First approval
1974
Drug indication
osteomyelitis
Bacterial infection
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cloxacillin sodium is an orally active antibacterial agent and ¦Â-lactamase inhibitor with an IC50 of 0.04 ¦ÌM. Cloxacillin sodium can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-§ÜB and NLRP3-related proteins[1][2][3].
DESCRIPTION
Cloxacillin is a semisynthetic beta-lactamase resistant penicillin antibacterial . It has less potent antibacterial activity than benzylpenicillin.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
74
Molecular Weight
435.07
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
2.55
TPSA
112.74
Fraction CSP3
0.37
Chiral centers
3.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
gram-positive bacterial infections
MOA
bacterial cell wall synthesis inhibitor
ATC
J01CF02
Target
antibiotic
Bacterial
Beta-lactamase
Therapeutic Class
Antibiotics
Pathway
Anti-infection
Source data
