General
Preferred name
DESIPRAMINE
Synonyms
DESIPRAMINE HYDROCHLORIDE ()
NSC-114901 ()
Desmethylimipramine ()
JB-8181 ()
EX-4355 ()
Norimipramine ()
G-35020 ()
Desipramine (HCl) ()
Desipramine (hydrochloride) ()
Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901 ()
Pertofran ()
EX 4355 ()
Desipramine hcl ()
Norpramin ()
Pertofrane ()
RMI-9384A ()
RMI 9,384A ()
DMI ()
18-8181 ()
Imipramine, demethyl- ()
Desipramina ()
Monodemethylimipramine ()
N-desmethylimipramine ()
Desipramine hydrochloride ()
DESIPRAMINA ()
IMIPRAMINE, DEMETHYL- ()
MONODEMETHYLIMIPRAMINE ()
N-DESMETHYLIMIPRAMINE ()
Desipramine-d4 (hydrochloride) ()
Desipramine (hydrochloride) (CRM) ()
P&D ID
PD009775
CAS
58-28-6
50-47-5
61361-34-0
Tags
available
drug
nuisance
biased GPCR ligand
Approved by
FDA
First approval
1964
Drug indication
small cell lung carcinoma
Attention deficit hyperactivity disorder
Post-traumatic stress disorder
Depression
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
PRICE 29
DESCRIPTION Desipramine is one of the tricyclic antidepressants. (GtoPdb)
DESCRIPTION Superoxide scavenger; antioxidant (Tocris Bioactive Compound Library)
DESCRIPTION Antidepressant (LOPAC library)
DESCRIPTION Desipramine is a tricyclic antidepressant that selectively blocks reuptake of norepinephrine from the neuronal synapse. It also inhibits serotonin reuptake, but to a lesser extent compared to tertiary amine TCAs such as imipramine. (Enamine Bioactive Compounds)
DESCRIPTION Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
4
Compound Sets
37
BiasDB
Desipramine
Cayman Chemical Bioactives
15304
19105
36849
ChEMBL Approved Drugs
CHEMBL1696
CHEMBL72
ChEMBL Drugs
CHEMBL1696
CHEMBL72
Concise Guide to Pharmacology 2017/18
2399
Concise Guide to Pharmacology 2019/20
2399
Concise Guide to Pharmacology 2021/22
2399
Concise Guide to Pharmacology 2023/24
2399
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01151
DrugBank Approved Drugs
DB01151
DrugCentral
812
DrugCentral Approved Drugs
812
DrugMAP
DMT2FDC
DrugMAP Approved Drugs
DMT2FDC
DrugMatrix
Enamine Bioactive Compounds
EBC-28045
EU-OPENSCREEN Bioactive Compound Library
EOS100774
EUbOPEN Chemogenomics Library
EUB0002555
Guide to Pharmacology
2399
Ki Database
DESIPRAMINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1696
CHEMBL72
MedChem Express Bioactive Compound Library
HY-B1272
NCATS Inxight Approved Drugs
TG537D343B
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
desipramine-hydrochloride
TargetMol Bioactive Compound Library
T0991
The Spectrum Collection
Tocris Bioactive Compound Library
3067
VGSC-DB
NA0017
External IDs
76
Properties
(calculated by RDKit )
Molecular Weight
266.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.53
TPSA
15.27
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
7.0
QED
0.85
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Target
5-HT
Adrenergic Receptor
Dopamine Transporter
Serotonin Transporter
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR1A, HTR2A, HTR2C, SLC6A2, SLC6A4, SMPD1
5-HT Receptor,Serotonin Transporter
Primary Target
Adrenergic Transporters
MOA
Inhibitor
Sodium Channel Blockers
Norepinephrine Transporter (NET) Inhibitors
tricyclic antidepressant
Member status
member
Indication
depression
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antidepressants
VGSC Target
Nav1.5
Recommended Cell Concentration
None
Source data