General
Preferred name
DESIPRAMINE
Synonyms
DESIPRAMINE HYDROCHLORIDE ()
Desmethylimipramine ()
Norimipramine ()
EX-4355 ()
G-35020 ()
JB-8181 ()
NSC-114901 ()
Desipramine (HCl) ()
Desipramine (hydrochloride) ()
Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901 ()
Desipramine-d4 (hydrochloride) ()
EX 4355 ()
RMI-9384A ()
Pertofrane ()
RMI 9,384A ()
Desipramine hcl ()
18-8181 ()
DMI ()
Norpramin ()
Pertofran ()
Imipramine, demethyl- ()
N-desmethylimipramine ()
Monodemethylimipramine ()
P&D ID
PD009775
CAS
58-28-6
50-47-5
61361-34-0
Tags
available
drug
biased GPCR ligand
nuisance
natural product
Approved by
FDA
First approval
1964
Drug indication
Depression
Antidepressant
Attention deficit hyperactivity disorder
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Desipramine is one of the tricyclic antidepressants.
(GtoPdb)
DESCRIPTION
Superoxide scavenger; antioxidant
(Tocris Bioactive Compound Library)
DESCRIPTION
Antidepressant
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
4
Compound Sets
35
BiasDB
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
VGSC-DB
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
71
Molecular Weight
266.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.53
TPSA
15.27
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
7.0
QED
0.85
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Target
5-HT
Adrenergic Receptor
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR1A, HTR2A, HTR2C, SLC6A2, SLC6A4, SMPD1
Dopamine Transporter
Serotonin Transporter
5-HT Receptor,Serotonin Transporter
Primary Target
Adrenergic Transporters
MOA
Inhibitor
Sodium Channel Blockers
Norepinephrine Transporter (NET) Inhibitors
tricyclic antidepressant
Member status
member
Indication
depression
Therapeutic Class
Antidepressants
VGSC Target
Nav1.5
Source data
