General
Preferred name
GEMIFLOXACIN
Synonyms
GEMIFLOXACIN MESYLATE ()
Gemifloxacin (mesylate) ()
SB-265805S ()
LB-20304a ()
Gemifloxacin (mesylate) ()
SB-265805-S ()
Gemifloxacin mesilate ()
LB 20304A ()
Factive ()
Gemifloxacin methanesulfonate ()
Gemifloxacino ()
Factiv ()
Gemifloxacine ()
P&D ID
PD009772
CAS
175463-14-6
210353-53-0
204519-65-3
Tags
available
drug
Approved by
KFDA
FDA
First approval
2002
2003
Drug indication
Bacterial infection
rhinoscleroma
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections[1][2][3].
DESCRIPTION
Gemifloxacin is a fluoroquinolone antibacterial compound with potent activity against both Gram-negative and Gram-positive microorganisms .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
389.15
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
0.97
TPSA
123.04
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
DNA gyrase inhibitor
Topoisomerase inhibitor
Target
antibiotic
Bacterial
DNA/RNA Synthesis
Topoisomerase
Therapeutic Class
Antibiotics
Pathway
Anti-infection
Cell Cycle/DNA Damage
Source data
