General
Preferred name
DINOPROST TROMETHAMINE
Synonyms
Prostaglandin F2a tromethamine salt ()
PGF2¦Á THAM ()
Prostaglandin F2¦Á THAM ()
Prostaglandin F2alpha ()
Dinoprost (tromethamine salt) ()
Prostaglandin F2α (tromethamine salt) ()
PGF2α THAM ()
Prostaglandin F2α THAM ()
Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol ()
Prostaglandin F2.alpha. (tromethamine salt) ()
Prostaglandin F2¦Á (tromethamine salt) ()
NSC-196515 ()
PGF2A THAM ()
Prostin F2 alpha ()
Prostaglandin f2.alpha. tromethamine salt ()
U-14-583E ()
PGF2ALPHA THAM ()
PGF2ALPHA-THAM ()
Lutalyse ()
U-14,583E ()
Prostaglandin F 2 Alpha ()
Dinoprost Trometamol ()
U-14583E ()
P&D ID
PD009769
CAS
38562-01-5
36300-07-9
Tags
available
drug
Drug indication
Abortion
Drug Status
vet_approved
approved
Max Phase
4.0
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dinoprost tromethamine salt (Prostaglandin F2¦Á tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour[1][2].
DESCRIPTION High affinity, selective AT1 antagonist (Tocris Bioactive Compound Library)
Compound Sets
10
Cayman Chemical Bioactives
16020
ChEMBL Approved Drugs
CHEMBL1200896
ChEMBL Drugs
CHEMBL1200896
DrugBank
DB01160
DrugBank Approved Drugs
DB01160
DrugMAP
DMXQKSL
DrugMAP Approved Drugs
DMXQKSL
MedChem Express Bioactive Compound Library
HY-12956A
Selleckchem Bioactive Compound Library
dinoprost-tromethamine
Tocris Bioactive Compound Library
4214
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
475.31
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
8
Rotatable Bonds
15
Ring Count
1
Aromatic Ring Count
0
cLogP
0.7
TPSA
184.7
Fraction CSP3
0.79
Chiral centers
5.0
Largest ring
5.0
QED
0.12
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Autophagy
Endogenous Metabolite
Prostaglandin Receptor
Primary Target
Prostanoid Receptors
MOA
Agonist
Therapeutic Class
Abortifacient Agents
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Source data