General
Preferred name
CHLOROPROCAINE
Synonyms
Chloroprocaine HCl ()
Chloroprocaine (hydrochloride) ()
CHLOROPROCAINE HYDROCHLORIDE ()
2-Chloroprocaine (hydrochloride) ()
Ampres ()
Chlorprocaine Chloride ()
Nesacaine-Mpf ()
Nesacaine ()
Clorotekal ()
2-chloroprocaine ()
P&D ID
PD009768
CAS
3858-89-7
133-16-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1955
Drug Status
investigational
approved
Drug indication
Anaesthesia
Anesthetic (local)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chloroprocaine is a short-acting ester anaesthetic. It has a significantly shorter duration of action than and is significantly less toxic. (GtoPdb)
PHARMACODYNAMICS Chloroprocaine is an ester type anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine.
Compound Sets
18
ChEMBL Approved Drugs
CHEMBL944
CHEMBL1179047
ChEMBL Drugs
CHEMBL944
CHEMBL1179047
Drug Repurposing Hub
DrugBank
DB01161
DrugBank Approved Drugs
DB01161
DrugCentral
605
DrugCentral Approved Drugs
605
DrugMAP
DMSOQK1
DrugMAP Approved Drugs
DMSOQK1
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7145
MedChem Express Bioactive Compound Library
HY-B1604
NCATS Inxight Approved Drugs
5YVB0POT2H
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
chloroprocaine-hci
TargetMol Bioactive Compound Library
T6443
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
270.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
2.42
TPSA
55.56
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
local anesthetic
Target
ATP1A1, CHRNA10, GRIN3A, HTR3A, SCN10A, SLC6A3
Na+/K+ ATPase
Sodium Channel
MOA
Sodium Channel blocker
Therapeutic Class
Anesthetics
Pathway
Membrane Transporter/Ion Channel
Source data