General
Preferred name
ORPHENADRINE
Synonyms
ORPHENADRINE CITRATE ()
Orphenadrine hydrochloride ()
ORPHENADRINE (CHLORIDE) ()
Banflex ()
Flexon ()
Flexoject ()
Mebedrol ()
Mephenamin ()
Orphenadrine (citrate) ()
Norflex4682-36-4 ()
Norflex ()
Orphenadine Citrate ()
Orphenadrine dihydrogen citrate ()
NSC-757238 ()
Norgesic ()
Orphengesic ()
Orphenadrin ()
Mialgin ()
Invagesic ()
Mefenamine ()
Disipal ()
Orphenadrine HCl ()
Biorphen ()
Orphenadrine Chloride ()
NSC-82357 ()
Orphenadrine (chloride) ()
Orphenadrine (hydrochloride) ()
P&D ID
PD009762
CAS
4682-36-4
83-98-7
341-69-5
4596-23-0
4724-58-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1957
1959
Drug Status
approved
Drug indication
Parkinson disease
Antihistaminic
Relaxant (skeletal muscle)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculo skeletal conditions.
DESCRIPTION Orphenadrine is a muscle relaxant.
Marketed formulations contain the citrate salt (PubChem CID 83823) or the hydrochloride (PubChem CID 9568).. (GtoPdb)
DESCRIPTION Muscarinic acetylcholine receptor antagonist; H1 histamine receptor antagonist (LOPAC library)
DESCRIPTION A skeletal muscle relaxant used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
28
AdooQ Bioactive Compound Library
A11712
BOC Sciences Bioactive Compounds
orphenadrine-hydrochloride-cas-341-69-5-66545
Cayman Chemical Bioactives
26391
ChEMBL Approved Drugs
CHEMBL1200395
CHEMBL1201023
CHEMBL900
ChEMBL Drugs
CHEMBL1200395
CHEMBL1201023
CHEMBL900
DrugBank
DB01173
DrugBank Approved Drugs
DB01173
DrugCentral
1999
DrugCentral Approved Drugs
1999
DrugMAP
DMW542E
DrugMAP Approved Drugs
DMW542E
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101225
Guide to Pharmacology
7251
JUMP-MOA Compound Set
4601
Ki Database
Orphenadrine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL900
MedChem Express Bioactive Compound Library
HY-B0369A
NCATS Inxight Approved Drugs
AL805O9OG9
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
orphenadrine-citrate-norflex
orphenadrine-hydrochloride
TargetMol Bioactive Compound Library
T6618
T1308
The Spectrum Collection
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
269.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.66
TPSA
12.47
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Muscarinic
Target
iGluR
AChR
H1 receptor
NMDA Receptor
Noradrenaline transporter (Sodium-dependent)
Sodium Channel
NMDAR
Pathway
Neuronal Signaling
Neuroscience
GPCR/G protein
Membrane Transporter/Ion Channel
Immunology/Inflammation
MOA
acetylcholine receptor antagonist
Therapeutic Class
Antiparkinson Agents
Solubility
Soluble in DMSO
Source data