General
Preferred name
ACEBUTOLOL
Synonyms
ACEBUTOLOL HYDROCHLORIDE ()
Acebutolol HCl ()
Acebutolol (hydrochloride) ()
Sectral 400 ()
Sectral ()
Neptal ()
NSC-757412 ()
Prent ()
IL-17803A ()
B-17803A ()
M&B-17803A ()
M&B 17803A ()
Acetanol ()
Acebut HCl ()
Sectral 200 ()
B 17803A ()
M& ()
C07AB04 ()
Acebutolol-d7 ()
P&D ID
PD009749
CAS
34381-68-5
37517-30-9
28197-63-9
2701782-36-5
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Acebutolol hydrochloride is an orally active ¦Â1 adrenergic receptor (¦Â1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias[1][2][3].
DESCRIPTION
Acebutolol is a β-blocker.
(GtoPdb)
DESCRIPTION
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
27
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
66
Molecular Weight
336.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
10
Ring Count
1
Aromatic Ring Count
1
cLogP
2.37
TPSA
87.66
Fraction CSP3
0.56
Chiral centers
1.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Adrenergic Receptor
β-adrenergic receptor
ADRB1
Indication
hypertension, ventricular arrhythmias
MOA
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antihypertensive Agents
Source data
