General
Preferred name
brinzolamide
Synonyms
AL-4862 ()
Azopt ()
NSC-760050 ()
Brinzolamide-d5 ()
P&D ID
PD009748
CAS
138890-62-7
1217651-02-9
Tags
natural product
drug
available
Approved by
PMDA
EMA
FDA
First approval
1998
Drug Status
approved
Drug indication
Antiglaucoma Agent
Open-angle glaucoma
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Carbonic anhydrase inhibitor (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
A11765
Cayman Chemical Bioactives
11660
30006
ChEMBL Approved Drugs
CHEMBL220491
ChEMBL Drugs
CHEMBL220491
Concise Guide to Pharmacology 2017/18
6797
Concise Guide to Pharmacology 2019/20
6797
Concise Guide to Pharmacology 2021/22
6797
Drug Repurposing Hub
DrugBank
DB01194
DrugBank Approved Drugs
DB01194
DrugCentral
396
DrugCentral Approved Drugs
396
DrugMAP
DMBAPFG
DrugMAP Approved Drugs
DMBAPFG
EU-OPENSCREEN Bioactive Compound Library
EOS100597
Guide to Pharmacology
6797
JUMP-Target 1 Compound Set
68844
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL220491
MedChem Express Bioactive Compound Library
HY-B0588
NCATS Inxight Approved Drugs
9451Z89515
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
brinzolamide
TargetMol Bioactive Compound Library
T0142
ZINC Tool Compounds
ZINC000003953037
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
383.06
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
0.09
TPSA
118.8
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Carbonic anhydrase II
CA1, CA12, CA14, CA2, CA4, CA5A, CA7
CA5A
Carbonic Anhydrase
Indication
intraocular pressure, glaucoma, ocular hypertension
MOA
Carbonic anhydrase inhibitor
Therapeutic Class
Antiglaucomic Agents
Source data