General
Preferred name
FLECAINIDE
Synonyms
FLECAINIDE ACETATE ()
Flecainide (acetate) ()
R-818 ()
Flecainide hydrochloride ()
Flecainide (hydrochloride) ()
Flecainide monoacetate ()
Tambocor ()
FLECAINIDE COMPONENT OF THN-102 ()
Flecainide component of thn102 ()
NSC-719273 ()
Flecainida ()
flecainide ()
P&D ID
PD009747
CAS
54143-56-5
54143-55-4
57415-44-8
Tags
available
drug
Approved by
FDA
First approval
1985
Drug indication
Atrial fibrillation
Paroxysmal atrial fibrillation
Tachyarrhythmias
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
PRICE 40
DESCRIPTION Flecainide is a class Ic antiarrhythmic agent. (GtoPdb)
DESCRIPTION Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT)[1][2].
DESCRIPTION Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT)[1][2][3].
PRICE 91
DESCRIPTION GABA-mimetic; selectively interacts with beta2- and beta3-subunit containing GABAA receptors (Tocris Bioactive Compound Library)
DESCRIPTION Cardiac Na+ channel blocker. Antiarrhythmic (Tocriscreen Plus)
DESCRIPTION Sodium channel blocker; Class I antiarrythmic agent (LOPAC library)
DESCRIPTION Cardiac Na+ channel blocker. Antiarrhythmic (Tocriscreen Total)
DESCRIPTION Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormally fast heart rhythms). (TargetMol Bioactive Compound Library)
DESCRIPTION Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
31
Cayman Chemical Bioactives
20388
ChEMBL Approved Drugs
CHEMBL1200822
CHEMBL652
ChEMBL Drugs
CHEMBL1200822
CHEMBL652
Drug Repurposing Hub
DrugBank
DB01195
DrugBank Approved Drugs
DB01195
DrugCentral
1176
DrugCentral Approved Drugs
1176
DrugMAP
DMSQDLE
DrugMAP Approved Drugs
DMSQDLE
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
2560
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL652
Mcule NIBR MoA Box Subset
MCULE-3327347453
MedChem Express Bioactive Compound Library
HY-17429
HY-W010950
HY-W010950A
NCATS Inxight Approved Drugs
K94FTS1806
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
flecainide
TargetMol Bioactive Compound Library
T7219
T8581
The Spectrum Collection
Tocris Bioactive Compound Library
1470
Tocriscreen Plus
1470
Tocriscreen Total
VGSC-DB
NA0019
NA5921
Withdrawn 2.0
DB01195
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
414.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
3.44
TPSA
59.59
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
Nav1.5 channel
Sodium Channel
KCNA5, KCNA7, SCN5A
Potassium Channel
Primary Target
Voltage-gated Sodium (NaV) Channels
MOA
Blocker
Nav1.5 (Cardiac/SkMII) Sodium Channel Blockers
Sodium Channel blocker
Member status
member
Indication
ventricular tachycardia (VT), atrial fibrillation (AF), ventricular arrhythmias
ATC
C01BC04
Therapeutic Class
Antiarrhythmic Agents
VGSC Target
Nav1.5
Nav1.9
Pathway
Membrane Transporter/Ion Channel
Source data