General
Preferred name
tubocurarine
Synonyms
TUBOCURARINE CHLORIDE PENTAHYDRATE ()
Tubocurarine ()
Jexin ()
Tubarine ()
TUBOCURARINE CHLORIDE ()
(+)-Tubocurarine chloride ()
NSC-757362 ()
Tubocurarini chloridum ()
Curare ()
Tubocurarine chloride, anhydrous ()
Cloruro de tubocurarina ()
Chlorure de tubocurarine ()
Tubarine pentahydrate ()
Tubocurarine chloride anhydrous ()
Tubocurarine chloride hydrochloride hydrate ()
Tubaine ()
Tubocurarine cation ()
d-Tubocurarine ()
Tubocurarine ion ()
P&D ID
PD009744
CAS
6989-98-6
57-94-3
57-95-4
1370-17-8
1390-11-0
8063-06-7
1406-69-5
41354-45-4
Tags
available
drug
natural product
Approved by
FDA
First approval
1945
Drug indication
Smoking dependence
Anaesthesia
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tubocurarine is a skeletal muscle relaxant. The structure as specified by the FDA and the INN document shows the compound in complex with chloride (see PubChem CID 9917490). As our data specifies the parent compound, it is this structure we have chosen to display here, and which the majority of entries linked to from the table above display.
(GtoPdb)
DESCRIPTION
Selective KV11.1 (hERG) channel activator
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
20
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
79
Molecular Weight
609.3
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
8
Aromatic Ring Count
4
cLogP
6.7
TPSA
80.62
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
18.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Nicotinic Receptors (Non-selective)
MOA
Antagonist
acetylcholine receptor antagonist
Target
ACHE, CHRNA2, HTR3A, HTR3B, KCNN1, KCNN2, KCNN3, ZACN
Indication
anesthetic
ATC
M03AA02
Therapeutic Class
Neuromuscular Nondepolarizing Agents
Source data
