General
Preferred name
SPARFLOXACIN
Synonyms
AT-4140 ()
CI-978 ()
PD 131501 ()
Zagam ()
AT-4140, CI-978, PD 131501,Zagam ()
NSC-759641 ()
Spara ()
P&D ID
PD009739
CAS
110871-86-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1996
Drug Status
investigational
approved
withdrawn
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sparfloxacin is a fluoroquinolone antibacterial. It has a less than ideal side-effect profile that led to its withdrawl from the US market.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
392.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
2.08
TPSA
100.59
Fraction CSP3
0.47
Chiral centers
2.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Anti-infection
Target
DNA gyrase
Topo II
Topo IV
TOP2A
antibiotic
Bacterial
Antibiotics,Bacterial
MOA
bacterial DNA gyrase inhibitor
ATC
J01MA09
Toxicity type
cardiovascular
Therapeutic Class
Antibiotics
Source data
