General
Preferred name
levobunolol
Synonyms
(-) -Levobunolol hydrochloride ()
Levobunolol (hydrochloride) ()
Levobunolol?HCl ()
LEVOBUNOLOL HYDROCHLORIDE ()
l-Bunolol hydrochloride ()
W 7000A ()
W-7000A ()
Levobunolol hcl ()
Betagan ()
Akbeta ()
NSC-759158 ()
Bunolol, (s)- ()
Bunolol, (-)- ()
Levobunolol (hydrochloride) ()
P&D ID
PD009737
CAS
27912-14-7
47141-42-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1985
Drug Status
approved
Drug indication
Open-angle glaucoma
Anti-Adrenergic (beta-receptor)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Levobunolol is a nonselective β-adrenoceptor antagonist. (GtoPdb)
Compound Sets
21
Cayman Chemical Bioactives
21005
ChEMBL Approved Drugs
CHEMBL1201177
CHEMBL1201237
ChEMBL Drugs
CHEMBL1201177
CHEMBL1201237
Concise Guide to Pharmacology 2017/18
570
Concise Guide to Pharmacology 2019/20
570
Concise Guide to Pharmacology 2021/22
570
Concise Guide to Pharmacology 2023/24
570
Drug Repurposing Hub
DrugBank
DB01210
DrugBank Approved Drugs
DB01210
DrugCentral
431
DrugCentral Approved Drugs
431
DrugMAP
DMTNFCQ
DrugMAP Approved Drugs
DMTNFCQ
Guide to Pharmacology
570
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201237
MedChem Express Bioactive Compound Library
HY-B1035
NCATS Inxight Approved Drugs
G6317AOI7K
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
291.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
2.33
TPSA
58.56
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
glaucoma, ocular hypertension
Target
ADRB1, ADRB2, ADRB3
Adrenergic Receptor
MOA
Adrenergic Receptor antagonist
Therapeutic Class
Sympatholytics
Pathway
GPCR/G protein
Neuronal Signaling
Source data