General
Preferred name
CLAVULANIC ACID
Synonyms
CLAVULANATE LITHIUM ()
Clavulanate potassium salt ()
Clavulanate ()
Clavulanate+Amoxicillin ()
clavulanic acid, Rexahn ()
CLAVULANATE POTASSIUM ()
BRL-14151K ()
Potassium clavulanate ()
BRL 14151K ()
BRL 14151 ()
RX-10100 ()
Serdaxin ()
BRL-14151 ()
Clavulanate (potassium salt) ()
P&D ID
PD009731
CAS
61177-45-5
58001-44-8
1365254-41-6
Tags
covalent binder
nuisance
natural product
drug
available
Approved by
FDA
First approval
1984
Drug Status
approved
vet_approved
Drug indication
Inhibitor (beta-lactamase)
Bacterial infection
Infectious disease
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clavulanic acid is a β-lactamase inhibitor that was isolated from Streptomyces clavuligerus . It is used in combination with β-lactam antibacterials and does not have inherent antibacterial activity. Clavulanic acid can overcome antibacterial resistance in bacteria that secrete β-lactamase. Included in the WHO Essential Medicines list as the mixture of amoxicillin + clavulanic acid (co-amoxiclav). (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
22
Cayman Chemical Bioactives
19456
ChEMBL Approved Drugs
CHEMBL1003
CHEMBL777
ChEMBL Drugs
CHEMBL1003
CHEMBL777
CovalentInDB
CI000182
CovBinderInPDB
CBR000737
CBR001580
CBR002509
CBR002510
CBR002512
CBR002513
CBR002933
CBR004362
CBR004363
Drug Repurposing Hub
DrugBank
DB00766
DrugBank Approved Drugs
DB00766
DrugCentral
669
DrugCentral Approved Drugs
669
DrugMAP
DMAJNYM
DM2FGRT
DrugMAP Approved Drugs
DM2FGRT
Guide to Pharmacology
11128
Mcule NIBR MoA Box Subset
MCULE-3963000692
MedChem Express Bioactive Compound Library
HY-A0256
NCATS Inxight Approved Drugs
23521W1S24
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
External IDs
73
Properties
(calculated by RDKit )
Molecular Weight
199.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.1
TPSA
87.07
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
5.0
QED
0.55
Structural alerts
1
Beta lactamase inhibition
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
beta-Lactamase Inhibitors
beta lactamase inhibitor
Indication
otitis
Therapeutic Class
Antibiotics
Pathway
Anti-infection
Target
antibiotic
Bacterial
Beta-lactamase
Source data