General
Preferred name
tirofiban
Synonyms
Tirofiban HCl ()
MK-383 ()
TIROFIBAN HYDROCHLORIDE ()
MK-383 Hydrochloride ()
Tirofiban hydrochloride monohydrate ()
Tirofiban HCl Hydrate ()
Tirofiban (hydrochloride monohydrate) ()
L700462 (hydrochloride monohydrate) ()
MK383 (hydrochloride monohydrate) ()
L700462 ()
MK383 ()
L-700,462 ()
Aggrastat ()
Tirofiban hydrochloride anhydrous ()
L-700462 ()
Agrastat ()
Tirofiban (hydrochloride hydrate) ()
P&D ID
PD009726
CAS
150915-40-5
144494-65-5
142373-60-2
1331911-68-2
Tags
available
drug
Approved by
FDA
First approval
1998
Drug Status
approved
Drug indication
Acute coronary syndrome
Treatment of Unstable Angina
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tirofiban is a rapidly-active but short-acting glycoprotein IIb/IIIa inhibitor type antiplatelet drug. (GtoPdb)
DESCRIPTION Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
1
Compound Sets
27
AdooQ Bioactive Compound Library
A13783
BOC Sciences Bioactive Compounds
tirofiban-cas-144494-65-5-58831
Cayman Chemical Bioactives
23392
ChEMBL Approved Drugs
CHEMBL3189072
CHEMBL916
ChEMBL Drugs
CHEMBL3189072
CHEMBL916
Concise Guide to Pharmacology 2017/18
6586
Concise Guide to Pharmacology 2019/20
6586
Concise Guide to Pharmacology 2021/22
6586
Concise Guide to Pharmacology 2023/24
6586
Drug Repurposing Hub
DrugBank
DB00775
DrugBank Approved Drugs
DB00775
DrugCentral
2680
DrugCentral Approved Drugs
2680
DrugMAP
DMQG17S
DrugMAP Approved Drugs
DMQG17S
EU-OPENSCREEN Bioactive Compound Library
EOS100015
Guide to Pharmacology
6586
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL916
MedChem Express Bioactive Compound Library
HY-17369
HY-17369B
NCATS Inxight Approved Drugs
GGX234SI5H
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tirofiban-hydrochlorid
TargetMol Bioactive Compound Library
T2537
External IDs
75
Properties
(calculated by RDKit )
Molecular Weight
440.23
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
14
Ring Count
2
Aromatic Ring Count
1
cLogP
2.95
TPSA
104.73
Fraction CSP3
0.68
Chiral centers
1.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
Membrane Transporter/Ion Channel
cytoskeleton
Target
GPIIb/IIIa
ADP
ITGA2B, ITGB3
Integrin
Member status
member
MOA
Integrin binder
Integrin alpha-2/beta-3 antagonist
platelet aggregation inhibitor, structural glycoprotein antagonist
Indication
myocardial infarction, refactory angina
Therapeutic Class
Fibrinolytic Agents
Source data