General
Preferred name
PROPIOMAZINE
Synonyms
1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone monohydrochloride ()
Propiomazine ()
PROPIOMAZINE HYDROCHLORIDE ()
Propavan ()
WY-1359 ()
Propiomazina ()
Indorm ()
CB 1678 ()
Dorevane ()
CB-1678 ()
Dorevan ()
Largon ()
Propiomazine HCl ()
P&D ID
PD009725
CAS
362-29-8
1240-15-9
Tags
available
drug
Approved by
FDA
First approval
1960
Drug indication
Insomnia
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Propiomazine acts as an antagonist of dopamine 1, 2, and 4 receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect.
TOXICITY Although rare, serious adverse events may be seen with propiomazine. Such events include convulsions (seizures), difficult or unusually fast breathing, fast or irregular heartbeat or pulse, fever (high), high or low blood pressure, loss of bladder control, muscle stiffness (severe), unusual increase in sweating, unusually pale skin, and unusual tiredness or weakness.
DESCRIPTION Propiomazine is an antipsychotic drug.
Marketed formulations may contain propiomazine hydrochloride (PubChem CID 71802). (GtoPdb)
PRICE 817
DESCRIPTION Propiomazine is an orally active antihistamine compound with sedative effects, used for controlling insomnia in neurological diseases. (TargetMol Bioactive Compound Library)
Compound Sets
15
ChEMBL Approved Drugs
CHEMBL1201210
CHEMBL1201068
ChEMBL Drugs
CHEMBL1201210
CHEMBL1201068
DrugBank
DB00777
DrugBank Approved Drugs
DB00777
DrugCentral
2298
DrugCentral Approved Drugs
2298
DrugMAP
DMKY8V1
DrugMAP Approved Drugs
DMKY8V1
DrugMatrix
Guide to Pharmacology
7284
MedChem Express Bioactive Compound Library
HY-U00051
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T61088
Withdrawn 2.0
290
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
340.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
4.83
TPSA
23.55
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
ATC
N05CM06
Therapeutic Class
Sedatives and Hypnotics
Target
Histamine Receptor
Source data