General
Preferred name
PROPIOMAZINE
Synonyms
1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone monohydrochloride ()
Propiomazine ()
PROPIOMAZINE HYDROCHLORIDE ()
Dorevane ()
Dorevan ()
Indorm ()
Propavan ()
CB-1678 ()
CB 1678 ()
WY-1359 ()
Largon ()
Propiomazine HCl ()
P&D ID
PD009725
CAS
362-29-8
1240-15-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1960
Drug Status
approved
withdrawn
Drug indication
Sedative (pre-anesthetic)
Insomnia
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Propiomazine is an antipsychotic drug.
Marketed formulations may contain propiomazine hydrochloride (PubChem CID 71802). (GtoPdb)
TOXICITY Although rare, serious adverse events may be seen with propiomazine. Such events include convulsions (seizures), difficult or unusually fast breathing, fast or irregular heartbeat or pulse, fever (high), high or low blood pressure, loss of bladder control, muscle stiffness (severe), unusual increase in sweating, unusually pale skin, and unusual tiredness or weakness.
MOA Propiomazine acts as an antagonist of dopamine 1, 2, and 4 receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect.
Compound Sets
13
ChEMBL Approved Drugs
CHEMBL1201210
CHEMBL1201068
ChEMBL Drugs
CHEMBL1201210
CHEMBL1201068
DrugBank
DB00777
DrugBank Approved Drugs
DB00777
DrugCentral
2298
DrugCentral Approved Drugs
2298
DrugMAP
DMKY8V1
DrugMAP Approved Drugs
DMKY8V1
DrugMatrix
Guide to Pharmacology
7284
NPC Screening Collection
ReFrame library
Withdrawn 2.0
290
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
340.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
4.83
TPSA
23.55
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
N05CM06
Therapeutic Class
Sedatives and Hypnotics
Source data