General
Preferred name
PROPANTHELINE
Synonyms
PROPANTHELINE BROMIDE ()
Pro-Banthine ()
Neometantyl ()
Neopepulsan ()
Propantheline (bromide) ()
Pro-Banthine50-34-0 ()
Pro-Banthine, Neometantyl, Neopepulsan ()
NSC-757294 ()
Propantheline ion ()
Propantheline cation ()
P&D ID
PD009722
CAS
50-34-0
298-50-0
Tags
available
drug
Approved by
FDA
First approval
1953
Drug Status
approved
Drug indication
Excessive sweating
Anticholinergic
Stomach ulcer
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Propantheline is a non-selective muscarinic acetylcholine receptor antagonist.
(GtoPdb)
DESCRIPTION
Muscarinic acetylcholine receptor antagonist; antispasmodic
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
23
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
368.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
4.73
TPSA
35.53
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Muscarinic
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Target
mAChR
CHRM1, CHRM2, CHRM3, CHRM4
AChR
Indication
peptic ulcer disease (PUD)
MOA
acetylcholine receptor antagonist
Therapeutic Class
Antispasmodics
Source data
