General
Preferred name
perindopril
Synonyms
PERINDOPRIL ERBUMINE ()
S9490-3 ()
Perindopril tert-butylamine salt ()
Perindopril Erbumine (Aceon) ()
PERINDOPRIL ARGININE ()
IC980033 ()
Perindopril (erbumine) ()
S-9490 ()
Perindopril (tert-butylamine salt) ()
S-9490 (erbumine) ()
NSC-758929 ()
Aceon ()
Coversyl ()
Perindopril tert-butylamine ()
Perindopril erbumine component of amlessa ()
S-9490-3 ()
McN-A-2833-109 ()
McN-A-2833 ()
Perindopril arginine component of prestalia ()
P&D ID
PD009719
CAS
107133-36-8
82834-16-0
99149-83-4
612548-45-5
Tags
available
drug
drug candidate
prodrug
Approved by
FDA
First approval
1993
2015
Drug indication
Cardiovascular disease
Discovery agent
Hypertension
Drug Status
investigational
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-¦ÊB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure[1][2][3][4].
DESCRIPTION
Prodrug metabolically converted to the drug perindoprilat. Perindopril erbumine [USAN] aka perindopril tert-butylamine, is PubChem CID 441313.
(GtoPdb)
DESCRIPTION
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest
(Tocris Bioactive Compound Library)
DESCRIPTION
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril erbumine (S9490-3) is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Perindopril is a long-acting ACE inhibitor. It is used to treat patients with hypertension, diabetes mellitus type 2, coronary heart disease, chronic heart failure or stable coronary artery disease in form of perindopril arginine on the basis of a large evidence. lt has anticancer activity through the inhibition of tumor growth and angiogenesis in hepatocellular carcinoma cells. It suppresses angiotensin II production in vitro. In the in vitro cell proliferation assays, it does not show significant effect on the cell proliferation. In vivo assays demonstrate it can suppress the growth of SCC-VII cells. It is reported that 8 mg perindopril given orally can lower blood pressure without a change in heart rate. It was developed by Xoma.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
23
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
157
Molecular Weight
368.23
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
0
cLogP
1.94
TPSA
95.94
Fraction CSP3
0.84
Chiral centers
5.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACE
Apoptosis
MRP1
Angiotensin Receptor
Angiotensin-converting Enzyme (ACE)
Sirtuin
STAT
Primary Target
Angiotensin-Converting Enzyme
MOA
MRP inhibitor
RAAS inhibitor
Inhibitor
angiotensin converting enzyme inhibitor
Indication
hypertension, myocardial infarction, coronary artery disease (CAD)
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Cell Cycle/DNA Damage
Epigenetics
JAK/STAT Signaling
Metabolic Enzyme/Protease
NF-κB
Stem Cell/Wnt
Endocrinology/Hormones
Immunology/Inflammation
NF-¦ÊB
Solubility
Soluble in water, chloroform, methanol
Source data
