General
Preferred name
TRIPELENNAMINE
Synonyms
TRIPELENNAMINE CITRATE ()
2-(Benzyl(2-(dimethylamino)ethyl)amino)pyridine citrate (1:1) ()
Pyribenzamine hydrochloride ()
Tripelennamine HCl ()
Pyribenzamine HCl ()
TRIPELENNAMINE HYDROCHLORIDE ()
Tripelennamine ()
Tripelennamine (hydrochloride) ()
NSC-757360 ()
PBZ ()
Pyribenzamine ()
Azaron ()
NSC-409943 ()
Vetibenzamina ()
Dehistin ()
PBZ-SR ()
NSC-118946 ()
Tripelenamina ()
P&D ID
PD009718
CAS
6138-56-3
22306-05-4
154-69-8
91-81-6
Tags
available
drug
Approved by
FDA
First approval
1948
Drug indication
Hypersensitivity
Pruritus
Drug Status
approved
vet_approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tripelennamine hydrochloride, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine hydrochloride lessens the allergic response of the organism caused by histamine. Tripelennamine hydrochloride can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].
PRICE
29
DESCRIPTION
Tripelennamine is a first-generation antihistamine. It also has serotonin reuptake inhibitor (SRI) activity, and was used as the template molecule in the development of the selective serotonin reuptake inhibitor (SSRI) . In addition, tripelennamine has dopamine reuptake inhibitor (DRI) activity.
(GtoPdb)
DESCRIPTION
Tripelennamine is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is a psychoactive drug that is used as an antipruritic and first-generation antihistamine.
(Enamine Bioactive Compounds)
DESCRIPTION
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
24
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
67
Molecular Weight
255.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.65
TPSA
19.37
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Indication
asthma, allergic rhinitis, urticaria
Disease Area
pulmonary, allergy
Target
HRH1
Endogenous Metabolite
Histamine Receptor
H1 receptor
MOA
Histamine Receptor antagonist
ATC
D04AA04
R06AC04
Therapeutic Class
Antiallergic Agents
Source data
