General
Preferred name
TOLAZOLINE
Synonyms
TOLAZOLINE HYDROCHLORIDE ()
Priscol ()
Benzalolin ()
Priscoline ()
Divascol ()
Vasimid ()
Imidaline hydrochloride ()
Imidaline (hydrochloride) ()
Benzidazol hydrochloride ()
Tolazoline HCl ()
NSC35110 (hydrochloride) ()
NSC35110 (hydrochloride)Imidaline (hydrochloride)Tolazoline HCl ()
Tolazoline ()
Tolazoline HCl ()
Tolazoline (hydrochloride) ()
Imidaline ()
NSC35110 ()
Imidaline hydrochloride,NSC35110 hydrochloride ()
Benzidazol ()
TCMDC-125842 ()
NSC-757353 ()
NSC-35110 ()
Tolazine ()
Tolazolina ()
P&D ID
PD009716
CAS
59-97-2
59-98-3
245547-27-7
Tags
available
drug
Approved by
FDA
First approval
1948
1985
Drug indication
Pulmonary hypertension
Cardiovascular disease
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tolazoline hydrochloride (Imidaline hydrochloride) is an ¦Á-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, ¦Á2-adrenergic receptor agonist-related poisoning, and skin vascular disease research[1][2][3][4][5][6][7].
PRICE 29
DESCRIPTION Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive ??-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn.
DESCRIPTION Tolazoline is a non-selective α-adrenoceptor antagonist. (GtoPdb)
DESCRIPTION Tolazoline (Imidaline) is an ¦Á-adrenergic receptor antagonist. Tolazoline inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline can be used to study erectile dysfunction, ¦Á2-adrenergic receptor agonist-related poisoning, and skin vascular disease research[1][2][3][4][5][6][7].
PRICE 29
DESCRIPTION Tolazoline (Benzalolin), a non-selective competitive ??-adrenergic receptor antagonist, is used as a vasodilator to treat spasms of peripheral blood vessels. It has also been used successfully as an antidote to reverse the severe peripheral vasoconstriction as a result of overdose with certain 5-HT2A agonist drugs.
DESCRIPTION Tolazoline HCl is a competitive alpha1- and alpha2-adrenergic receptor antagonist. It is used in veterinary medicine as reversal agent for the sedative effects of alpha2-adrenergic receptor. (Enamine Bioactive Compounds)
DESCRIPTION Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. (TargetMol Bioactive Compound Library)
DESCRIPTION Tolazoline (Benzalolin), a non-selective competitive α-adrenergic receptor antagonist, is used as a vasodilator to treat spasms of peripheral blood vessels. It has also been used successfully as an antidote to reverse the severe peripheral vasoconstriction as a result of overdose with certain 5-HT2A agonist drugs. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
31
Cayman Chemical Bioactives
18865
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1689
CHEMBL770
ChEMBL Drugs
CHEMBL1689
CHEMBL770
Concise Guide to Pharmacology 2017/18
7310
Concise Guide to Pharmacology 2019/20
7310
Concise Guide to Pharmacology 2021/22
7310
Concise Guide to Pharmacology 2023/24
7310
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00797
DrugBank Approved Drugs
DB00797
DrugCentral
2695
DrugCentral Approved Drugs
2695
DrugMAP
DMI40NL
DrugMAP Approved Drugs
DMI40NL
DrugMatrix
Enamine Bioactive Compounds
EBC-03430
Enamine BioReference Compounds
Guide to Pharmacology
7310
Ki Database
TOLAZOLINE
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL770
MedChem Express Bioactive Compound Library
HY-A0066A
HY-A0066
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tolazoline-hcl
TargetMol Bioactive Compound Library
T1680
T21447
The Spectrum Collection
Withdrawn 2.0
59
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
160.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
1.23
TPSA
24.39
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Adrenergic Receptor antagonist
Target
Adrenergic receptor alpha
Histamine H1 receptor
Histamine H2 receptor
α-adrenergic receptor
Adrenergic Receptor
ADRA1A, ADRA2A, ADRA2B, ADRA2C, HRH1, HRH2
Indication
reverse sedative
ATC
M02AX02
C04AB02
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Vasodilator Agents
Source data