General
Preferred name
DICYCLOMINE
Synonyms
DICYCLOMINE HYDROCHLORIDE ()
dicycloverine ()
Dicyclomine (hydrochloride) ()
Bentyl ()
Dicycloverine (hydrochloride) ()
Dicyclomine HCl ()
Dicycloverine HCl ()
Dicycloverine (Dicyclomine) ()
Dicyclomine Hydrochloride (Preservative-Free) ()
Bentyl preservative free ()
Merbentyl ()
NSC-404381 ()
Wyovin ()
Dicycloverine hydrochloride ()
Bentylol ()
Dicyclomine hydrochloride (preservative free) ()
Kolantyl hydrochloride ()
Merbentyl 20 ()
Kolantyl ()
Dicymine ()
Dicycloverine ()
Dicyclomine ()
P&D ID
PD009709
CAS
67-92-5
104959-55-9
77-19-0
Tags
natural product
drug
available
Approved by
FDA
First approval
1950
Drug Status
approved
withdrawn
Drug indication
Anticholinergic
Functional bowel syndrome
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION For the treatment of functional bowel/irritable bowel syndrome; including Colicky abdominal pain; diverticulitis
DESCRIPTION Dicyclomine is a non-selective muscarinic acetylcholine receptor antagonist. (GtoPdb)
DESCRIPTION Competitive muscarinic acetylcholine receptor antagonist (LOPAC library)
DESCRIPTION Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist. It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbacho) in guinea pig cortex. Dicyclomine inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats. Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract. (BOC Sciences Bioactive Compounds)
DESCRIPTION Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
28
BOC Sciences Bioactive Compounds
dicyclomine-hydrochloride-cas-67-92-5-item-75032
dicycloverine-dicyclomine-cas-77-19-0-item-76913
Cayman Chemical Bioactives
23867
ChEMBL Approved Drugs
CHEMBL1200479
CHEMBL1123
ChEMBL Drugs
CHEMBL1200479
CHEMBL1123
Drug Repurposing Hub
DrugBank
DB00804
DrugBank Approved Drugs
DB00804
DrugCentral
868
DrugCentral Approved Drugs
868
DrugMAP
DMZSDGX
DrugMAP Approved Drugs
DMZSDGX
DrugMatrix
Guide to Pharmacology
355
Ki Database
Dicyclomine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200479
CHEMBL1123
Mcule NIBR MoA Box Subset
MCULE-9110194493
MedChem Express Bioactive Compound Library
HY-B1339
NCATS Inxight Approved Drugs
CQ903KQA31
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
dicyclomine-hcl
TargetMol Bioactive Compound Library
T1460
The Spectrum Collection
Withdrawn 2.0
w185
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
309.27
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
0
cLogP
4.4
TPSA
29.54
Fraction CSP3
0.95
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Muscarinic
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Target
mAChR
CHRM1, CHRM2, CHRM3
Member status
member
MOA
Muscarinic M1 Antagonists
acetylcholine receptor antagonist
Indication
irritable bowel syndrome
ATC
A03AA07
Toxicity type
multiple
Therapeutic Class
Anticholinergic Agents
Solubility
Soluble in DMSO
Source data