General
Preferred name
BROMPHENIRAMINE
Synonyms
BROMPHENIRAMINE MALEATE ()
2-(P-bromo-a-(2-(dimethylamino)ethyl)benzyl)pyridine ()
(±)-Brompheniramine maleate ()
dexbrompheniramine ()
Dimotane ()
Rolabromophen ()
Brompheniramine hydrogen maleate ()
Dimetane ()
d-brompheniramine ()
d,l-Bromopheniramine ()
Brompheniramine (maleate) ()
(±)-Brompheniramine (maleate) ()
Brompheniramine maleate component of myphetane dc ()
Brompheniramine maleate component of bromanate ()
Dimotane L.A. ()
Dimetane-Ten ()
NSC-758652 ()
Brompheniramine maleate component of biphetap ()
Brompheniramine maleate component of bromanate dm ()
Dimegan ()
(+)-Brompheniramine Maleate ()
Brompheniramine maleate component of bromanate dc ()
Brompheniramine maleate component of bromfed-dm ()
Brompheniramine maleate component of bromatapp ()
Brompheniramine maleate component of dimetapp ()
Brompheniramine maleate component of dimetane-dc ()
Brompheniramine maleate component of dimetane-dx ()
(¡À)-Brompheniramine (maleate) ()
Dimetapp ()
Bromfeniramina ()
Bromfed ()
BPN ()
Brotane ()
Lodrane ()
Bromfenex ()
P&D ID
PD009699
CAS
980-71-2
86-22-6
156428-33-0
102282-22-4
32865-01-3
132-21-8
Tags
available
drug
Approved by
FDA
First approval
1957
Drug indication
Cough
Allergic rhinitis
allergic disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Brompheniramine ((¡À)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 ¦ÌM, 16.12 ¦ÌM and 21.26 ¦ÌM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research[1][2][3][4].
MOA Brompheniramine is an antagonist of the H1 histamine receptors with moderate antimuscarinic actions, as with other common antihistamines such as diphenhydramine. Due to its anticholindergic effects, brompheniramine may cause drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.
DESCRIPTION Brompheniramine is a racemic mixture of stereoisomers. We show the non-isomeric molecule to represent the mixture. The pharmacologically active isomer is . (GtoPdb)
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
DESCRIPTION Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors. (TargetMol Bioactive Compound Library)
DESCRIPTION Brompheniramine an antihistamine drug.It belongs to the propylamine class. It can be used for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine also has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin and norepinephrine. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
27
AdooQ Bioactive Compound Library
A11699
BOC Sciences Bioactive Compounds
brompheniramine-hydrogen-maleate-cas-980-71-2-349427
brompheniramine-cas-86-22-6-item-78533
Cayman Chemical Bioactives
20996
ChEMBL Approved Drugs
CHEMBL1200961
CHEMBL811
ChEMBL Drugs
CHEMBL1200961
CHEMBL811
DrugBank
DB00835
DrugBank Approved Drugs
DB00835
DrugCentral
408
DrugCentral Approved Drugs
408
DrugMAP
DMFOVSD
DrugMAP Approved Drugs
DMFOVSD
DrugMatrix
Guide to Pharmacology
7133
Ki Database
Brompheniramine
d-brompheniramine
d,l-Bromopheniramine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL811
Mcule NIBR MoA Box Subset
MCULE-7399471364
MedChem Express Bioactive Compound Library
HY-B0480
NCATS Inxight Approved Drugs
H57G17P2FN
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
brompheniramine
TargetMol Bioactive Compound Library
T0205
The Spectrum Collection
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
318.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.93
TPSA
16.13
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Member status
member
MOA
Histamine Receptor Antagonists
Target
Calcium Channel
Histamine Receptor
mAChR
Potassium Channel
Sodium Channel
HT
Therapeutic Class
Antiallergic Agents
Solubility
Soluble in DMSO
Source data