General
Preferred name
LOPERAMIDE
Synonyms
LOPERAMIDE HYDROCHLORIDE ()
R-18553 ()
Loperamide HCl ()
R-18553 (hydrochloride) ()
ADL 2-1294 ()
R-18553 (hydrochloride)Loperamide HCl ()
Loperamide HCl ()
Loperamide (hydrochloride) ()
ADL 2-1294,R-18553 hydrochloride ()
IMODIUM INSTANTS ()
NORMALOE ()
IMODIUM A-D EZ CHEWS ()
DIAH-LIMIT ()
DIAREZE ()
DIORALEZE ()
ENTROCALM ()
GPPE PACK ()
IMODIUM A-D ()
IMODIUM LIQUICAPS ()
NORIMODE ()
IMODIUM IBS RELIEF ()
DIOCAPS ()
LOPERAMIDI HYDROCHLORIDUM ()
IMODIUM ()
DIOCALM ()
Loperamide hydrochloride component of imodium multi-symptom relief ()
DIASORB ()
LODIAR ()
ARRET ()
IMODIUM CLASSIC ()
DIARRHOEA RELIEF ()
Imodium advanced ()
R 18,553 ()
DIAQUITTE ()
IMODIUM INSTANT MELTS ()
LOPERAGEN ()
NSC-696356 ()
Loperamida ()
LOPERAMIDE HYDROCHLORIDE COMPONENT OF IMODIUM MULTI-SYMPTOM RELIEF ()
P&D ID
PD009698
CAS
34552-83-5
53179-11-6
137524-29-9
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
1976
Drug indication
breast carcinoma
Diarrhea
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4].
PRICE 29
DESCRIPTION Loperamide is an opioid-receptor agonist used as an anti-diarrheal agent. Although unreported previously, recent clinical cases of severe cardiotoxicity (and death) due to high-dose loperamide abuse have been reported . (GtoPdb)
DESCRIPTION Meperidine congener which binds to opioid receptors; Ca2+ channel antagonist (LOPAC library)
DESCRIPTION Peripherally acting μ agonist. Also Ca2+ channel blocker (Tocriscreen Total)
DESCRIPTION Muscarinic agonist (Tocris Bioactive Compound Library)
DESCRIPTION Loperamide is a long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. (Enamine Bioactive Compounds)
DESCRIPTION Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
8
Compound Sets
42
BiasDB
Loperamide
Cayman Chemical Bioactives
14875
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1707
CHEMBL841
ChEMBL Drugs
CHEMBL1707
CHEMBL841
Concise Guide to Pharmacology 2017/18
7215
Concise Guide to Pharmacology 2019/20
7215
Concise Guide to Pharmacology 2021/22
7215
Concise Guide to Pharmacology 2023/24
7215
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00836
DrugBank Approved Drugs
DB00836
DrugCentral
1599
DrugCentral Approved Drugs
1599
DrugMAP
DMOJZQ9
DrugMAP Approved Drugs
DMOJZQ9
DrugMatrix
Enamine Bioactive Compounds
EBC-11156
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101675
EUbOPEN Chemogenomics Library
EUB0000447
Guide to Pharmacology
7215
JUMP-Target 1 Compound Set
3955
Ki Database
Loperamide
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1707
CHEMBL841
Mcule NIBR MoA Box Subset
MCULE-3957783776
MedChem Express Bioactive Compound Library
HY-B0418A
NCATS Inxight Approved Drugs
77TI35393C
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Loperamide-hydrochloride
TargetMol Bioactive Compound Library
T0209
The Spectrum Collection
Tocris Bioactive Compound Library
0840
Tocriscreen Total
Withdrawn 2.0
w117
ZINC Tool Compounds
ZINC000000537928
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
476.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
5.09
TPSA
43.78
Fraction CSP3
0.34
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Opioid Receptor agonist
Agonist
mu-Opioid Agonists
Target
Mu opioid receptor
CACNA1A, CALM1, OPRD1, OPRK1, OPRM1, POMC
OPRM1
Opioid Receptor
Autophagy,Opioid Receptor
δ-opioid receptor
κ-opioid receptor
μ-opioid receptor
Primary Target
? Opioid Receptors
Member status
member
Indication
diarrhea
ATC
A07DA03
Toxicity type
gastrointestinal
Pathway
Autophagy
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antidiarrheals
Recommended Cell Concentration
100 nM
Source data