General
Preferred name
DONEPEZIL
Synonyms
DONEPEZIL HYDROCHLORIDE ()
2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxyindan-1-one ()
E 2020 ()
E2020 ()
Donepezilo ()
Aricept ()
BNAG ()
Donepezil HCl ()
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) ()
Donepezil (Hydrochloride) ()
E2020 (free base) ()
Aricept, Donepezilo ()
Donepezil-d4 (hydrochloride) ()
Aricept Odt ()
Aricept Evess ()
NSC-758882 ()
NSC-737535 ()
Adlarity ()
Donepezil hydrochloride component of namzaric ()
E-2020 ()
Donaz ()
D-797 ()
P&D ID
PD009693
CAS
120011-70-3
120014-06-4
110119-84-1
1219798-88-5
Tags
available
drug
drug candidate
Approved by
PMDA
FDA
First approval
1996
Drug indication
Alzheimer disease
Cognitive impairment
Discovery agent
Dementia
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on A¦Â42 neurotoxicity[2].
DESCRIPTION
May be refered to as donepezil hydrochloride (PubChem CID 5741). In addition to the original brand, Aricept, generic donepezil formulations are now approved by the US FDA.
(GtoPdb)
DESCRIPTION
Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
PRICE
40
DESCRIPTION
Potent O-GlcNAcase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE).It is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior.
(Enamine Bioactive Compounds)
DESCRIPTION
Donepezil (Aricept) is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
0
Compound Sets
35
Axon Medchem Screening Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
82
Molecular Weight
379.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
4.36
TPSA
38.77
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
bAChE
hAChE
AChE inhibitor
Cholinesterase (ChE)
Primary Target
Cholinesterases
MOA
AChR
Inhibitor
Acetylcholinesterase Inhibitors
Member status
member
Pathway
Neuroscience
Neuronal Signaling
Therapeutic Class
Neurology Agents
Source data
