General
Preferred name
DONEPEZIL
Synonyms
DONEPEZIL HYDROCHLORIDE ()
2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxyindan-1-one ()
E2020 ()
Aricept ()
Donepezilo ()
BNAG ()
E 2020 ()
Donepezil HCl ()
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) ()
Donepezil (Hydrochloride) ()
E2020 (free base) ()
Aricept, Donepezilo ()
NSC-758882 ()
Adlarity ()
NSC-737535 ()
Aricept Evess ()
Aricept Odt ()
E-2020 ()
Donaz ()
D-797 ()
Donepezil-d4 (hydrochloride) ()
P&D ID
PD009693
CAS
120014-06-4
120011-70-3
110119-84-1
1219798-88-5
Tags
drug candidate
natural product
drug
available
Approved by
PMDA
FDA
First approval
1996
Drug Status
approved
Drug indication
Discovery agent
Inhibitor (acetylcholinesterase)
Alzheimer's Disease Treatment (adjunct)
Alzheimer disease
Cognition Adjuvant
Dementia Symptoms Treatment Adjunct
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION May be refered to as donepezil hydrochloride (PubChem CID 5741). In addition to the original brand, Aricept, generic donepezil formulations are now approved by the US FDA. (GtoPdb)
DESCRIPTION Potent O-GlcNAcase inhibitor (Tocris Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
34
AdooQ Bioactive Compound Library
A10330
A13079
Axon Medchem Screening Library
1438
Cayman Chemical Bioactives
18251
13245
ChEMBL Approved Drugs
CHEMBL1678
CHEMBL502
ChEMBL Drugs
CHEMBL1678
CHEMBL502
Concise Guide to Pharmacology 2017/18
6599
Concise Guide to Pharmacology 2019/20
6599
Concise Guide to Pharmacology 2021/22
6599
Concise Guide to Pharmacology 2023/24
6599
DrugBank
DB00843
DrugBank Approved Drugs
DB00843
DrugCentral
946
DrugCentral Approved Drugs
946
DrugMAP
DMIYG7Z
DMDAN0K
DrugMAP Approved Drugs
DMIYG7Z
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101603
Guide to Pharmacology
6599
Ki Database
E 2020
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1678
CHEMBL502
Mcule NIBR MoA Box Subset
MCULE-5214537955
MedChem Express Bioactive Compound Library
HY-B0034
HY-14566
NCATS Inxight Approved Drugs
8SSC91326P
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Donepezil-hydrochloride(Aricept)
donepezil
TargetMol Bioactive Compound Library
T6478
T7041
The Spectrum Collection
Tocris Bioactive Compound Library
4385
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
379.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
4.36
TPSA
38.77
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Neuronal Signaling
Target
AChE
bAChE
hAChE
AChE inhibitor
Cholinesterase (ChE)
Primary Target
Cholinesterases
MOA
AChR
Inhibitor
Acetylcholinesterase Inhibitors
Member status
member
Therapeutic Class
Neurology Agents
Source data