General
Preferred name
TERBINAFINE
Synonyms
TERBINAFINE HYDROCHLORIDE ()
CPD000469152 ()
TDT 067 ()
SF 86-327 ()
Lamisil ()
Terbinex ()
TDT 067 hydrochloride ()
Terbinafine HCl ()
KWD 2019 ()
KWD 201,KWD 2019,TDT 067 hydrochloride ()
SF 86-327,TDT 067 ()
Terbine ()
Bramizil ()
Bramazil ()
Terbina ()
Muzonal ()
Athlete's Foot ()
Lamisil Once ()
Terbinafine (as hydrochloride) ()
NSC-759113 ()
Lamisil at ()
SF-86-327 ()
TDT-067 ()
Terbinafine (hydrochloride) ()
Terbinafine-d3 (hydrochloride) ()
P&D ID
PD009684
CAS
91161-71-6
78628-80-5
1310012-15-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1992
Drug Status
investigational
approved
vet_approved
Drug indication
Antifungal
Fungal infection
Onychomycosis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive (Tocris Bioactive Compound Library)
DESCRIPTION Terbinafine HCl inhibits squalene epoxidase, preventing biosynthesis of ergosterol. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
18
Compound Sets
29
AdooQ Bioactive Compound Library
A10912
Axon Medchem Screening Library
3379
Bioprocess diversity set
BOC Sciences Bioactive Compounds
terbinafine-cas-91161-71-6-79456
Cayman Chemical Bioactives
10011619
26392
ChEMBL Approved Drugs
CHEMBL1200832
CHEMBL822
ChEMBL Drugs
CHEMBL1200832
CHEMBL822
Drug Repurposing Hub
DrugBank
DB00857
DrugBank Approved Drugs
DB00857
DrugCentral
2597
DrugCentral Approved Drugs
2597
DrugMAP
DMI6HUW
DrugMAP Approved Drugs
DMI6HUW
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100708
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL822
MedChem Express Bioactive Compound Library
HY-17395
HY-17395A
NCATS Inxight Approved Drugs
G7RIW8S0XP
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Terbinafine-hydrochloride-Lamisil
Terbinafine(Lamisil)
TargetMol Bioactive Compound Library
T1411
T6702
The Spectrum Collection
Tocris Bioactive Compound Library
6484
ZINC Tool Compounds
ZINC000001530981
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
291.2
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.88
TPSA
3.24
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Biological process
Resipration, oxidative phosphorylation, & mitochondrial targeting
Pathway
Microbiology&virology
Anti-infection
Target
squalene epoxidase
SQLE
Antifungal agent
antibiotic
Bacterial
Fungal
Primary Target
Two-P Potassium Channels
MOA
Activator
fungal squalene epoxidase inhibitor
Indication
tinea pedis, tinea cruris, tinea corporis
Therapeutic Class
Antifungal Agents
Source data