General
Preferred name
TERBINAFINE
Synonyms
TERBINAFINE HYDROCHLORIDE ()
CPD000469152 ()
Terbinex ()
SF 86-327 ()
Lamisil ()
TDT 067 ()
KWD 2019 ()
Terbinafine HCl ()
TDT 067 hydrochloride ()
KWD 201,KWD 2019,TDT 067 hydrochloride ()
SF 86-327,TDT 067 ()
Terbinafine (hydrochloride) ()
Terbine ()
Bramazil ()
Lamisil at ()
Lamisil Once ()
Terbina ()
Bramizil ()
Muzonal ()
Athlete's Foot ()
Terbinafine (as hydrochloride) ()
NSC-759113 ()
TDT-067 ()
Terbinafina ()
Lamasil ()
SF-86-327 ()
Terbinafine component of osurnia ()
Terbinafine-d3 (hydrochloride) ()
P&D ID
PD009684
CAS
91161-71-6
78628-80-5
1310012-15-7
Tags
available
drug
Approved by
FDA
First approval
1992
Drug indication
Onychomycosis
Fungal infection
Tinea pedis
Drug Status
vet_approved
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 29
DESCRIPTION Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 29
DESCRIPTION Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive (Tocris Bioactive Compound Library)
DESCRIPTION Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes. (TargetMol Bioactive Compound Library)
DESCRIPTION Terbinafine HCl inhibits squalene epoxidase, preventing biosynthesis of ergosterol. (BOC Sciences Bioactive Compounds)
DESCRIPTION Terbinafine is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase, an enzyme that is part of the fungal cell wall synthesis pathway. It is used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections. (Enamine Bioactive Compounds)
DESCRIPTION Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important component of fungal cell membranes. As a result, this agent disrupts fungal cell membrane synthesis and inhibits fungal growth. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
18
Compound Sets
30
AdooQ Bioactive Compound Library
A10912
Axon Medchem Screening Library
3379
Bioprocess diversity set
BOC Sciences Bioactive Compounds
terbinafine-cas-91161-71-6-79456
Cayman Chemical Bioactives
10011619
26392
ChEMBL Approved Drugs
CHEMBL1200832
CHEMBL822
ChEMBL Drugs
CHEMBL1200832
CHEMBL822
Drug Repurposing Hub
DrugBank
DB00857
DrugBank Approved Drugs
DB00857
DrugCentral
2597
DrugCentral Approved Drugs
2597
DrugMAP
DMI6HUW
DrugMAP Approved Drugs
DMI6HUW
Enamine Bioactive Compounds
EBC-12634
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100708
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL822
MedChem Express Bioactive Compound Library
HY-17395
HY-17395A
NCATS Inxight Approved Drugs
G7RIW8S0XP
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Terbinafine-hydrochloride-Lamisil
Terbinafine(Lamisil)
TargetMol Bioactive Compound Library
T1411
T6702
The Spectrum Collection
Tocris Bioactive Compound Library
6484
ZINC Tool Compounds
ZINC000001530981
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
291.2
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.88
TPSA
3.24
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Biological process
Resipration, oxidative phosphorylation, & mitochondrial targeting
Pathway
Microbiology/virology
Anti-infection
Primary Target
Two-P Potassium Channels
MOA
Activator
fungal squalene epoxidase inhibitor
Indication
tinea pedis, tinea cruris, tinea corporis
Target
SQLE
Antifungal agent
antibiotic
Bacterial
Fungal
squalene epoxidase
Therapeutic Class
Antifungal Agents
Source data