General
Preferred name
VARDENAFIL
Synonyms
VARDENAFIL HYDROCHLORIDE ()
Vardenafil HCl Trihydrate ()
BAY38-9456 ()
Vardenafil hydrochloride trihydrate ()
VARDENAFIL DIHYDROCHLORIDE ()
Vardenafil (hydrochloride) ()
Vardenafil (hydrochloride trihydrate) ()
BAY38-9456, Levitra, Staxyn ()
Vardenafil hcl ()
BAY 38-9456 ()
Vardenafil hydrochloride anhydrous ()
Nuviva ()
Levitra ()
BAY-38-9456 ()
Staxyn ()
Vardenafil hydrochloride hydrate ()
Vardenafil monohydrochloride ()
BAY-389456 ()
Vivanza ()
NSC-759103 ()
Vardenafil (hydrochloride hydrate) ()
Vardenafil-d5 ()
P&D ID
PD009681
CAS
330808-88-3
224785-90-4
1193386-64-9
224785-91-5
224789-15-5
1189685-70-8
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
2003
Drug Status
approved
Drug indication
Erectile dysfunction
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vardenafil is a phosphodiesterase type 5 (PDE5A) inhibitor. Marketed formulations may contain vardenafil hydrochloride (PubChem CID 10142962). (GtoPdb)
Compound Sets
30
AdooQ Bioactive Compound Library
A10965
Axon Medchem Screening Library
3396
Cayman Chemical Bioactives
14930
25225
ChEMBL Approved Drugs
CHEMBL1339
CHEMBL1520
ChEMBL Drugs
CHEMBL1339
CHEMBL1520
CHEMBL2106480
Concise Guide to Pharmacology 2017/18
7320
Concise Guide to Pharmacology 2019/20
7320
Concise Guide to Pharmacology 2021/22
7320
Concise Guide to Pharmacology 2023/24
7320
Drug Repurposing Hub
DrugBank
DB00862
DrugBank Approved Drugs
DB00862
DrugCentral
2809
DrugCentral Approved Drugs
2809
DrugMAP
DMTBGW8
DrugMAP Approved Drugs
DMTBGW8
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101178
Guide to Pharmacology
7320
Ki Database
vardenafil
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1339
CHEMBL1520
MedChem Express Bioactive Compound Library
HY-B0442A
HY-B0442B
HY-B0442
NCATS Inxight Approved Drugs
UCE6F4125H
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
vardenafil-hydrochloride
Vardenafil(Vivanza)
TargetMol Bioactive Compound Library
T4097
The Spectrum Collection
External IDs
123
Properties
(calculated by RDKit )
Molecular Weight
488.22
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
2.07
TPSA
112.9
Fraction CSP3
0.52
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
PDE1
PDE5
PDE5A, PDE6G, PDE6H
PDE5 inhibitor
Endogenous Metabolite
Phosphodiesterase (PDE)
PDE
Indication
erectile dysfunction
MOA
phosphodiesterase inhibitor
Therapeutic Class
Antiimpotence Agents
Source data