General
Preferred name
BENZPHETAMINE
Synonyms
BENZPHETAMINE HYDROCHLORIDE ()
Benzfetamine ()
U-0441 ()
Benzfetamine hydrochloride ()
Benzphetamine Chloride ()
Benzphetamine hcl ()
NSC-10937 ()
Benzphetamine hydrochloride ciii ()
Didrex ()
Benzphetamine (hydrochloride) ()
P&D ID
PD009679
CAS
156-08-1
5411-22-3
Tags
available
drug
Approved by
FDA
First approval
1960
Drug Status
illicit
approved
Drug indication
Obesity
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
The mechanism of action of these drugs is not fully understood, however it may be similar to that of amphetamines. Amphetamines stimulate noepinephrine and dopamine release in nerve endings in the lateral hypothalamic feeding centre, decreasing appetite. This release is mediated by the binding of benzphetamine to centrally located adrenergic receptors.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
NCATS Inxight Approved Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
239.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.75
TPSA
3.24
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
