General
Preferred name
ALPRENOLOL
Synonyms
ALPRENOLOL HYDROCHLORIDE ()
dl-Alprenolol ()
(RS)-Alprenolol ()
Alpheprol ()
ALPRENOLOL,(-) ()
ALPRENOLOL,(+) ()
dl-Alprenolol(RS)-Alprenolol ()
Alprenolol (hydrochloride) ()
Alprenolol HCl ()
(RS)-Alprenolol hydrochloride ()
dl-Alprenolol hydrochloride ()
H 56/28 ()
Gubernal ()
Aptine ()
Dl-alprenolol chloride ()
Apllobal ()
Regletin ()
Yobir ()
Dimacor ()
Aptol duriles ()
NSC-759561 ()
P&D ID
PD009678
CAS
13707-88-5
13655-52-2
Tags
drug
drug candidate
natural product
biased GPCR ligand
available
First approval
1966
Drug indication
Hypertension
Anti-Adrenergic (beta-receptor)
Drug Status
experimental
approved
withdrawn
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The approved drug alprenolol is a racemic mixture of the R and S isomers. We show the non-stereo structure to represent the mixture. (GtoPdb)
DESCRIPTION beta Adrenoceptor antagonist (LOPAC library)
DESCRIPTION alpha1 agonist (Tocris Bioactive Compound Library)
DESCRIPTION Alprenolol hydrochloride is the hydrochloride salt of alprenolol, which is a non-selective 5-HT1A receptor antagonist and beta blocker. It is used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
A17781
BiasDB
Alprenolol
BOC Sciences Bioactive Compounds
alprenolol-hydrochloride-cas-13707-88-5-item-9794
Cayman Chemical Bioactives
25338
ChEMBL Drugs
CHEMBL1256179
CHEMBL266195
Concise Guide to Pharmacology 2017/18
563
Concise Guide to Pharmacology 2019/20
563
Concise Guide to Pharmacology 2021/22
563
Concise Guide to Pharmacology 2023/24
563
DrugBank
DB00866
DrugCentral
137
DrugCentral Approved Drugs
137
DrugMAP
DMYJ8Z3
DrugMatrix
Guide to Pharmacology
563
Ki Database
ALPRENOLOL
ALPRENOLOL,(+)
ALPRENOLOL,(-)
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1517A
HY-B1517
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
alprenolol-hydrochloride
TargetMol Bioactive Compound Library
T4560
The Spectrum Collection
Tocris Bioactive Compound Library
2806
Withdrawn 2.0
DB00866
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
249.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
2.15
TPSA
41.49
Fraction CSP3
0.47
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
Pathway
GPCR/G protein
Neuronal Signaling
Target
??-adrenergic receptor
5-HT
¦Â-adrenergic receptor
5-HT Receptor
Adrenergic Receptor
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Adrenergic Receptor antagonist
5-HT Receptor antagonist
Antagonist
ATC
C07AA01
Toxicity type
NULL
Therapeutic Class
Antiarrhythmic Agents
Source data