General
Preferred name
ALPRENOLOL
Synonyms
ALPRENOLOL HYDROCHLORIDE ()
ALPRENOLOL,(-) ()
ALPRENOLOL,(+) ()
dl-Alprenolol(RS)-Alprenolol ()
Alprenolol HCl ()
Alprenolol (hydrochloride) ()
(RS)-Alprenolol hydrochloride ()
dl-Alprenolol hydrochloride ()
(RS)-Alprenolol ()
dl-Alprenolol ()
Yobir ()
H-56/28 ()
Gubernal ()
Apllobal ()
Regletin ()
Aptol duriles ()
Dl-alprenolol chloride ()
Dimacor ()
H 56/28 ()
Aptine ()
NSC-759561 ()
P&D ID
PD009678
CAS
13707-88-5
13655-52-2
Tags
available
drug candidate
drug
biased GPCR ligand
First approval
1966
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
withdrawn
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective ¦Â-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].
PRICE 29
DESCRIPTION The approved drug alprenolol is a racemic mixture of the R and S isomers. We show the non-stereo structure to represent the mixture. (GtoPdb)
PRICE 29
DESCRIPTION Alprenolol (Alpheprol) is a non-selective ??-adrenergic receptor (??-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.
DESCRIPTION alpha1 agonist (Tocris Bioactive Compound Library)
DESCRIPTION beta Adrenoceptor antagonist (LOPAC library)
DESCRIPTION Alprenolol hydrochloride is the hydrochloride salt of alprenolol, which is a non-selective 5-HT1A receptor antagonist and beta blocker. It is used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically. (BOC Sciences Bioactive Compounds)
DESCRIPTION Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
27
AdooQ Bioactive Compound Library
A17781
BiasDB
Alprenolol
BOC Sciences Bioactive Compounds
alprenolol-hydrochloride-cas-13707-88-5-item-9794
Cayman Chemical Bioactives
25338
ChEMBL Drugs
CHEMBL1256179
CHEMBL266195
Concise Guide to Pharmacology 2017/18
563
Concise Guide to Pharmacology 2019/20
563
Concise Guide to Pharmacology 2021/22
563
Concise Guide to Pharmacology 2023/24
563
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00866
DrugCentral
137
DrugCentral Approved Drugs
137
DrugMAP
DMYJ8Z3
DrugMatrix
Guide to Pharmacology
563
Ki Database
ALPRENOLOL
ALPRENOLOL,(+)
ALPRENOLOL,(-)
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1517A
HY-B1517
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
alprenolol-hydrochloride
TargetMol Bioactive Compound Library
T22236
The Spectrum Collection
Tocris Bioactive Compound Library
2806
Withdrawn 2.0
DB00866
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
249.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
2.15
TPSA
41.49
Fraction CSP3
0.47
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
Target
5-HT Receptor
5-HT1A
¦Â-adrenergic receptor
Adrenergic Receptor
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Adrenergic Receptor antagonist
5-HT Receptor antagonist
Antagonist
ATC
C07AA01
Toxicity type
NULL
Therapeutic Class
Antiarrhythmic Agents
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data