General
Preferred name
Suprofen
Synonyms
Maldocil ()
Suprol ()
TN-762 ()
Profenal ()
suprofen, Cusi ()
Suprofen ()
R-25061 ()
P-2-thenoylhydratropic acid ()
P-(2-thenoyl)hydratropic acid ()
Suprofene ()
Srendam ()
Sutoprofen ()
R-25,061 ()
Racemic suprofen ()
Suprofeno ()
NSC-303611 ()
Sulproltin ()
Topalgic ()
suprofen ()
P&D ID
PD009675
CAS
40828-46-4
52780-13-9
52780-12-8
Tags
available
drug
Approved by
FDA
First approval
1988
1985
Drug indication
Miosis
rheumatic disease
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).
PRICE
35
DESCRIPTION
Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic activity.
(GtoPdb)
DESCRIPTION
Suprofen is an ibuprofen-type anti-inflammatory analgesic and antipyretic. Suprofen is a dual COX-1/COX-2 inhibitor, it binds to the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes, preventing the synthesis of prostaglandins and reducing the inflammatory response.
(Enamine Bioactive Compounds)
DESCRIPTION
Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
260.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.17
TPSA
54.37
Fraction CSP3
0.14
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX-1
COX-2
PGE synthase
COX
ATC
M01AE07
Toxicity type
renal
Therapeutic Class
Antiinflammatory Agents
Pathway
Immunology/Inflammation
Neuroscience
Source data
