General
Preferred name
CHLORHEXIDINE
Synonyms
CHLORHEXIDINE DIHYDROCHLORIDE ()
Chlorascrub swab ()
Hibitane diacetate ()
Chlorhexidine Acetate ()
Bactigras ()
CHLORHEXIDINE HYDROCHLORIDE ()
Chlorhexidine 2HCl ()
NSC-185 ()
Chlorhexidinum ()
Nolvasan ()
Rotersept ()
chlorhexidine dressing, Hercon ()
Chlorhexidine (dihydrochloride) ()
Chlorhexidine (diacetate) ()
Chlorhexidine?2HCl ()
CHLORHEXIDINE DIACETATE ()
Chlorhexidine digluconate ()
CHLORHEXIDINE GLUCONATE ()
CHLORHEXIDINE PHOSPHANILATE ()
Chlorhexidine (hydrochloride) ()
AY-5312 ()
Dantroche hibitane ()
NSC-756679 ()
Chlorhex HCl ()
Chlorhexidine HCl ()
Exidine ()
Gppe Wsh ()
Cepton ()
Brian Care ()
Steri-Stat ()
NSC-753971 ()
Tarodent ()
Clinivex ()
Hibiclens ()
Primahex ()
Savloclens ()
Acriflex ()
Prevacare ()
E-Z Scrub ()
Bacticlens ()
Sterexidine ()
Pharmaseal Scrub Care ()
Hydrex ()
Sterets Uniscrub ()
Chlorhexidine gluconate component of avagard ()
Cyteal ()
Tisept ()
Savlon Jnr ()
Aerocide 1 ()
Chlorhexidine gluconate component of soluprep ()
Corsodyl Daily ()
Chloraprep ()
Cx 1 ()
Gppe Soln ()
Hibispray ()
Paroex ()
Peridex ()
Chlorhexidine d-digluconate ()
Chg Scrub ()
Curasept ()
Dyna-Hex ()
Hibi ()
Savlodil ()
Sterets Unisept ()
Chlorhex Glucon ()
Chlorhexidine gluconate component of chloraprep ()
Phiso-Med ()
Microderm ()
Periochip ()
Corsodyl Daily Defence ()
Savlon Hc ()
Bioscrub ()
Sterets Tisept ()
HiBiTane Plus ()
Readyprep chg ()
Periogard ()
Uriflex-C ()
Eczmol ()
Cida-Stat ()
Dispray 1 ()
Gppe Tinct ()
Prevacare R ()
Hibiscrub ()
Chlohexidine gluconate ()
Dispray 2 ()
Corsodyl ()
Hibistat ()
Cetriclens Fte ()
Hibidil ()
Perio-kin ()
Hibicet ()
Cetriclens ()
Merfen-incolore ()
Avagard ()
Dentisept ()
Chlorhexadine ()
Clorhexidina ()
NSC-526936 ()
Chlorhexidini diacetas ()
BMY-30120 ()
WP-973 ()
CHP ()
Chlorhexidine (acetate hydrate) ()
Chlorhexidine-d8 (hydrochloride) ()
P&D ID
PD009668
CAS
3697-42-5
18472-51-0
55-56-1
56-95-1
77146-42-0
206986-79-0
2012598-75-1
Tags
available
drug candidate
drug
Approved by
FDA
First approval
1976
Drug indication
Chronic obstructive pulmonary disease
periodontitis
Bacterial infection
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
1.0
3.0
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis)[1][2][3].
PRICE 29
DESCRIPTION Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis)[1][2][3].
PRICE 29
PRICE 29
DESCRIPTION Chlorhexidine dihydrochloride (NSC-185) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. (TargetMol Bioactive Compound Library)
DESCRIPTION Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections. (TargetMol Bioactive Compound Library)
DESCRIPTION Chlorhexidine (Rotersept) is a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram-positive bacteria are more negatively charged, they are more sensitive to this agent. (TargetMol Bioactive Compound Library)
DESCRIPTION Chlorhexidine diacetate (Bactigras) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
4
Compound Sets
24
Cayman Chemical Bioactives
17343
26924
33463
ChEMBL Approved Drugs
CHEMBL4297088
CHEMBL790
ChEMBL Drugs
CHEMBL1484251
CHEMBL4297088
CHEMBL790
CHEMBL486819
CHEMBL2106050
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00878
DrugBank Approved Drugs
DB00878
DrugCentral
597
DrugCentral Approved Drugs
597
DrugMAP
DMQ9MVG
DrugMAP Approved Drugs
DMQ9MVG
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100586
Guide to Pharmacology
14052
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL790
MedChem Express Bioactive Compound Library
HY-B1145
HY-B1248
HY-W013699
NCATS Inxight Approved Drugs
R4KO0DY52L
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
chlorhexidine-hcl
chlorhexidine
chlorhexidine-diacetate
TargetMol Bioactive Compound Library
T1147
T14951
T1000
T1000L
The Spectrum Collection
External IDs
172
Properties
(calculated by RDKit )
Molecular Weight
504.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
10
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
2
cLogP
4.18
TPSA
167.58
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.14
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
CAT
HNMT
Cell wall
Apoptosis
Necroptosis
Indication
cosmetic, skin infections, gingivitis
Disease Area
dermatology, infectious disease, dental
MOA
membrane integrity inhibitor
Pathway
Microbiology/virology
Immunology/Inflammation
Anti-infection
Therapeutic Class
Antibiotics
Source data