General
Preferred name
EMTRICITABINE
Synonyms
FTC ()
Emtriva ()
BW1592 ()
(-)-Emtricitabine ()
EMTRICITABINE, (+/-)- ()
Genvoya-emtricitabine ()
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one ()
FTC, BW1592 ()
Emtricitabine (BW 1592) ()
Emtricitabinum ()
524W91 ()
Emtricitabine, (-)- ()
Emtricitabine component of genvoya ()
Emtricitabine component of atripla ()
Emtricitabine component of descovy ()
Emtricitabina ()
(-)-FTC ()
Emtricitabine component of symtuza ()
Emtricitabine component of biktarvy ()
Emtricitabine component of truvada ()
FTC-(-) ()
Emtricitabine component of eviplera ()
524-W-91 ()
Coviracil ()
Emtricitabine component of odefsey ()
Emtricitabine component of complera ()
BW-524W91 ()
Emtricitabine component of stribild ()
P&D ID
PD009667
CAS
143491-54-7
143491-57-0
Tags
available
prodrug
drug
Approved by
FDA
PMDA
EMA
First approval
2003
Drug indication
Human immunodeficiency virus infection
HIV-1 infection
Hepatitis B virus infection
Hepatitis virus infection
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral compound. (GtoPdb)
MOA Emtricitabine works by inhibiting reverse transcriptasem preventing transcription of HIV RNA to DNA. Emtricitabine is a synthetic nucleoside analogue of cytidine. It is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which is responsible for the inhibition of HIV-1 reverse transcriptase. It competes with the natural substrate deoxycytidine 5'-triphosphate and incorporates into nascent viral DNA, resulting in early chain termination. Therefore emtricitabine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate deoxycytidine 5'-triphosphate and by its incorporation into viral DNA. By inhibiting HIV-1 reverse transcriptase, emtricitabine can help to lower the amount of HIV, or "viral load", in a patient's body and can indirectly increase the number of immune system cells (called T cells or CD4+ T-cells).
DESCRIPTION Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 ¦ÌM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
PRICE 29
DESCRIPTION Emtricitabine is a nucleoside reverse transcriptase inhibitor with anti-human immunodeficiency virus (HIV) and hepatitis B virus activity, with an EC50 value of 0.01 ??M in PBMC cells, and can be used to study HIV infection.
DESCRIPTION Emtricitabine is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity. It is indicated in combination with other medications for the treatment of HIV-1 infections. (Enamine Bioactive Compounds)
DESCRIPTION Emtricitabine is a nucleoside reverse transcriptase inhibitor with anti-human immunodeficiency virus (HIV) and hepatitis B virus activity, with an EC50 value of 0.01 µM in PBMC cells, and can be used to study HIV infection. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
4
Compound Sets
24
AdooQ Bioactive Compound Library
A10349
Axon Medchem Screening Library
3305
Cayman Chemical Bioactives
16879
ChEMBL Approved Drugs
CHEMBL885
ChEMBL Drugs
CHEMBL885
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00879
DrugBank Approved Drugs
DB00879
DrugCentral
1003
DrugCentral Approved Drugs
1003
DrugMAP
DMBMUWZ
DrugMAP Approved Drugs
DMBMUWZ
Enamine Bioactive Compounds
EBC-07648
Enamine BioReference Compounds
Guide to Pharmacology
11244
MedChem Express Bioactive Compound Library
HY-17427
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
ULS8902U4O
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Emtricitabine
TargetMol Bioactive Compound Library
T6214
The Spectrum Collection
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
247.04
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.46
TPSA
90.37
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIV
Reverse Transcriptase
NRT inhibitor
Endogenous Metabolite
HBV,HIV,Reverse Transcriptase
Indication
human immunodeficiency virus (HIV-1)
MOA
nucleoside reverse transcriptase inhibitor
Biosynthetic Origin
Nucleoside
Therapeutic Indication
Antiviral
Therapeutic Class
Anti-HIV Agents
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Source data