General
Preferred name
quinapril
Synonyms
QUINAPRIL HYDROCHLORIDE ()
CI-906 ()
PD-109452-2 ()
Quinapril HCl ()
Quinapril (hydrochloride) ()
CI-906, PD-109452-2 ()
Quinapril (hydrochloride) ()
NSC-758222 ()
Accupril ()
Quinil ()
Quinapril hydrochloride component of accuretic ()
Accupro ()
CI 906 ()
Quinapril hydrochloride component of quinaretic ()
C09AA06 ()
Quinapril-d5 ()
P&D ID
PD009666
CAS
82586-55-8
85441-61-8
1279029-79-6
Tags
available
prodrug
drug
Approved by
FDA
First approval
1991
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quinapril (hydrochloride) (CI-906) is a proagent that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.
PRICE 29
DESCRIPTION Quinapril is a pro-drug, converted to its active metabolite, quinaprilat, in the liver.
Marketed formulations may contain quinapril hydrochloride (PubChem CID 54891). (GtoPdb)
DESCRIPTION Quinapril HCl is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat. ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. (Enamine Bioactive Compounds)
DESCRIPTION Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury. (TargetMol Bioactive Compound Library)
Compound Sets
23
AdooQ Bioactive Compound Library
A11736
Cayman Chemical Bioactives
21439
30735
ChEMBL Approved Drugs
CHEMBL1201011
CHEMBL1592
ChEMBL Drugs
CHEMBL1201011
CHEMBL1592
Drug Repurposing Hub
DrugBank
DB00881
DrugBank Approved Drugs
DB00881
DrugCentral
2340
DrugCentral Approved Drugs
2340
DrugMAP
DMR8H31
DrugMAP Approved Drugs
DMR8H31
Enamine Bioactive Compounds
EBC-02086
Enamine BioReference Compounds
Guide to Pharmacology
6350
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1592
MedChem Express Bioactive Compound Library
HY-B0477
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
quinapril-hydrochloride-accupril
TargetMol Bioactive Compound Library
T0805
The Spectrum Collection
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
438.22
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
2.57
TPSA
95.94
Fraction CSP3
0.4
Chiral centers
3.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACE
Angiotensin-converting Enzyme (ACE)
RAAS
Indication
hypertension, congestive heart failure, angioedema
MOA
angiotensin converting enzyme inhibitor
Therapeutic Class
Antihypertensive Agents
Pathway
Metabolic Enzyme/Protease
Endocrinology/Hormones
Source data