General
Preferred name
clomifene
Synonyms
clomiphene ()
CLOMIPHENE CITRATE ()
NSC 35770 ()
Clomifene citrate ()
Clomiphene ()
MER-41 ()
MRL-41 ()
NSC-35770 ()
Serophene ()
Clophene ()
Clostilbegyt ()
Clomifeni citras ()
Clomiphene citrate (1:1) ()
Chloramiphene ()
Milophene ()
Ikaclomine ()
Pergotime ()
Clomid ()
P&D ID
PD009665
CAS
50-41-9
911-45-5
Tags
natural product
drug
available
Approved by
PMDA
FDA
First approval
1967
Drug Status
investigational
approved
Max Phase
Phase 4
Drug indication
Anti-Estrogen
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clomiphene is an estrogen receptor alpha modulator, it can act an agonist or antagonist depending on the target tissue. The approved drug clomiphene is a racemic mixture of the two geometric isomers, E and Z clomiphene (also known as and zuclomiphene). Zuclomifene is the more active isomer. (GtoPdb)
ROE Based on early studies with 14C-labeled clomiphene citrate, the drug was shown to be readily absorbed orally in humans and excreted principally in the feces.; Mean urinary excretion was approximately 8% with fecal excretion of about 42%.
Cell lines
1
Organisms
2
Compound Sets
15
ChEMBL Approved Drugs
CHEMBL2355051
CHEMBL3185958
ChEMBL Drugs
CHEMBL2355051
CHEMBL3185958
Concise Guide to Pharmacology 2017/18
4159
Concise Guide to Pharmacology 2019/20
4159
Concise Guide to Pharmacology 2021/22
4159
Concise Guide to Pharmacology 2023/24
4159
DrugBank
DB00882
DrugBank Approved Drugs
DB00882
DrugCentral
700
DrugCentral Approved Drugs
700
DrugMatrix
Guide to Pharmacology
4159
NIH Clinical Collections (NCC)
NPC Screening Collection
TargetMol Bioactive Compound Library
T1193
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
405.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
3
cLogP
6.56
TPSA
12.47
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Target
ER
Source data