General
Preferred name
clomifene
Synonyms
clomiphene ()
Clomifene citrate ()
MRL-41 ()
Clostilbegyt ()
Milophene ()
Chloramiphene ()
Pergotime ()
Clomiphene citrate (1:1) ()
Clomid ()
NSC-35770 ()
Clophene ()
MER-41 ()
Ikaclomine ()
Clomifeni citras ()
Serophene ()
CLOMIPHENE CITRATE ()
Clomifeno ()
Clomiphene ()
P&D ID
PD009665
CAS
911-45-5
50-41-9
Tags
available
drug
Approved by
FDA
PMDA
First approval
1967
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
Hypogonadism
polycystic ovary syndrome
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clomiphene is an estrogen receptor alpha modulator, it can act an agonist or antagonist depending on the target tissue. The approved drug clomiphene is a racemic mixture of the two geometric isomers, E and Z clomiphene (also known as and zuclomiphene). Zuclomifene is the more active isomer. (GtoPdb)
ROE Based on early studies with 14C-labeled clomiphene citrate, the drug was shown to be readily absorbed orally in humans and excreted principally in the feces.; Mean urinary excretion was approximately 8% with fecal excretion of about 42%.
DESCRIPTION Clomifene is a selective ER modulator. Clomifene is used to induce ovulation. (Enamine Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
16
ChEMBL Approved Drugs
CHEMBL2355051
CHEMBL3185958
ChEMBL Drugs
CHEMBL2355051
CHEMBL3185958
Concise Guide to Pharmacology 2017/18
4159
Concise Guide to Pharmacology 2019/20
4159
Concise Guide to Pharmacology 2021/22
4159
Concise Guide to Pharmacology 2023/24
4159
Concise Guide to Pharmacology 2025/26
4159
DrugBank
DB00882
DrugBank Approved Drugs
DB00882
DrugCentral
700
DrugCentral Approved Drugs
700
DrugMatrix
Enamine Bioactive Compounds
EBC-97044
Guide to Pharmacology
4159
NIH Clinical Collections (NCC)
NPC Screening Collection
External IDs
138
Properties
(calculated by RDKit )
Molecular Weight
405.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
3
cLogP
6.56
TPSA
12.47
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Source data